INTERACTIONS OF THE SEROTONIN AND CIRCADIAN SYSTEMS: NATURE AND NURTURE IN RHYTHMS AND BLUES
INTERACTIONS OF THE SEROTONIN AND CIRCADIAN SYSTEMS: NATURE AND NURTURE IN RHYTHMS AND BLUES
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DOI：
10.1016/j.neuroscience.2011.09.036
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发表时间：
2011-12-01
期刊：
影响因子：
3.3
通讯作者：
McMahon, D. G.
中科院分区：
文献类型：
--
作者：
Ciarleglio, C. M.;Resuehr, H. E. S.;McMahon, D. G.
血清素和昼夜节律系统是大脑的主要调节网络。每一个都由一组独特的神经元组成，这些神经元建立了广泛的神经连接，以及一个由转录调节基因和信号基因组成的明确的基因网络，这些基因网络在遗传水平上辅助5-羟色胺能和昼夜节律功能。这些大脑的主要调节网络广泛地相互交织在一起，相互回路连接，在时钟神经元中表达5-羟色胺信号的关键遗传元件，在5-羟色胺能神经元中表达关键的时钟基因。5-羟色胺和昼夜节律系统的相互联系可能对神经行为障碍具有重要意义，这一点从它们对包括季节性情感障碍(SAD)、双相情感障碍和严重抑郁症在内的类似范围的情绪障碍的贡献中得到了说明，也从它们与发育障碍、自闭症谱系障碍的重叠关系中得到了说明。在这里，我们回顾了脑内5-羟色胺-昼夜节律相互作用的神经解剖学和遗传学基础，它们与神经行为障碍的潜在关系，以及最近的工作，考察了5-羟色胺能系统的遗传扰动对昼夜节律系统的影响，以及围产期季节性光周期对昼夜节律系统发育印记的分子和行为影响。(C)2011年由爱思唯尔有限公司代表IBRO出版。
The serotonin and circadian systems are principal regulatory networks of the brain. Each consists of a unique set of neurons that make widespread neural connections and a defined gene network of transcriptional regulators and signaling genes that subserve serotonergic and circadian function at the genetic level. These master regulatory networks of the brain are extensively intertwined, with reciprocal circuit connections, expression of key genetic elements for serotonin signaling in clock neurons and expression of key clock genes in serotonergic neurons. The reciprocal connections of the serotonin and circadian systems likely have importance for neurobehavioral disorders, as suggested by their convergent contribution to a similar range of mood disorders including seasonal affective disorder (SAD), bipolar disorder, and major depression, and as suggested by their overlapping relationship with the developmental disorder, autism spectrum disorder. Here we review the neuroanatomical and genetic basis for serotonin-circadian interactions in the brain, their potential relationship with neurobehavioral disorders, and recent work examining the effects on the circadian system of genetic perturbation of the serotonergic system as well as the molecular and behavioral effects of developmental imprinting of the circadian system with perinatal seasonal light cycles. (C) 2011 Published by Elsevier Ltd on behalf of IBRO.