Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion
Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion
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DOI：
10.1016/j.joen.2007.10.020
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发表时间：
2008-02-01
影响因子：
4.2
通讯作者：
Ribeiro, Martha Simoes
中科院分区：
文献类型：
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作者：
Garcez, Aguinaldo Silva;Nunez, Silvia Cristina;Ribeiro, Martha Simoes
本研究分析了光动力疗法（PDT）与根管治疗联合应用的抗菌效果。选择了20名患者。在进入根管、牙髓治疗和PDT后采集微生物样本。在第一次治疗结束时，根管填充Ca（OH）（2），1周后，进行第二次治疗。根管治疗平均减少1.08 log。与PDT的组合显著增强了减少（1.83 log，p = 0.00002）。第二次根管治疗与第一次（1.14 log）的减少相似，第二次PDT比第一次更有效（p = 0.002）。第二次总的减少是显着高于第二根管治疗（p = 0.0000005）。第一次+第二次总降低（3.19 log）与第一次组合显著不同（p = 0.00006）。结果表明，使用PDT添加到根管治疗导致细菌负荷的增强降低，可能是一种合适的方法用于治疗口腔感染。
This study analyzed the antimicrobial effect of photodynamic therapy (PDT) in association with endodontic treatment. Twenty patients were selected. Microbiological samples were taken after accessing the canal, endodontic therapy, and PDT. At the end of the first session, the root canal was filled with Ca(OH)(2), and after 1 week, a second session of the therapies was performed. Endodontic therapy gave a mean reduction of 1.08 log. The combination with PDT significantly enhanced the reduction (1.83 log, p = 0.00002). The second endodontic session gave a similar diminution to the first (1.14 log), and the second PDT was significantly more effective than the first (p = 0.002). The second total reduction was significantly higher than the second endodontic therapy (p = 0.0000005). The total first + second reduction (3.19 log) was significantly different from the first combination (p = 0.00006). Results suggest that the use of PDT added to endodontic treatment leads to an enhanced decrease of bacterial load and may be an appropriate approach for the treatment of oral infections.