Effects of the cyclo‐oxygenase inhibitor, fenbufen, on clenbuterol‐induced hypertrophy of cardiac and skeletal muscle of rats
Effects of the cyclo‐oxygenase inhibitor, fenbufen, on clenbuterol‐induced hypertrophy of cardiac and skeletal muscle of rats
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环加氧酶抑制剂芬布芬对克伦特罗诱导的大鼠心肌和骨骼肌肥大的影响
DOI：
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发表时间：
1990
影响因子：
7.3
通讯作者：
C. Maltin
中科院分区：
文献类型：
--
作者：
R. M. Palmer;M. Delday;D. N. Mcmillan;B. Noble;P. Bain;C. Maltin
1.大鼠连续7天服用克仑特罗后，强直性比目鱼肌和相位性跖肌的骨骼肌质量增加21%，心脏肥大16%。在同一时期喂给大鼠芬布芬，可以阻止心脏的肥大，但不能阻止骨骼肌的肥大。2当在给予克伦特罗前3天开始喂食芬布芬时，血浆前列腺素F2α（PGF 2 α）降低了79%;芬布芬对克伦特罗诱导的跖肌RNA或蛋白质含量增加以及比目鱼肌中快或慢收缩纤维面积增加也没有影响。在心脏中，克伦特罗诱导的RNA（+ 21%）和蛋白质含量（+ 20%）的增加被完全抑制。3克伦特罗对心肌的影响似乎是由花生四烯酸的环加氧酶代谢产物介导的，而对骨骼肌的影响则不是。
1 When rats were fed with clenbuterol for 7 days skeletal muscle mass increased by 21% in the tonic soleus and phasic plantaris muscles and a 16% hypertrophy of the heart was also induced. Fenbufen, fed to rats for the same period, blocked the hypertrophy of the heart but not that of the skeletal muscles. 2 When feeding of fenbufen commenced 3 days before the administration of clenbuterol, plasma prostaglandin F2α (PGF2α) was reduced by 79%; there was again no effect of fenbufen on clenbuterol‐induced increases in the RNA or protein content of plantaris, nor in the increased area of fast or slow twitch fibres in the soleus. In the heart the clenbuterol‐induced increases in the RNA (+ 21%) and protein content (+ 20%) were totally inhibited. 3 The effects of clenbuterol on heart muscle appear to be mediated by a cyclo‐oxygenase metabolite of arachidonic acid whilst the effects on skeletal muscle are not.
克伦特罗（一种 β2 受体激动剂）引起骨骼肌纤维从慢到快的变化。
DOI：
10.1152/ajpendo.1988.254.6.e726
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Zeman,RJ;Ludemann,R;Easton,TG;Etlinger,JD
通讯作者：
Etlinger,JD
骨骼肌中胰岛素结合的β-肾上腺素能调节。
DOI：
10.1152/ajpendo.1986.250.2.e198
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Webster,B;Vigna,SR;Paquette,T;Koerker,DJ
通讯作者：
Koerker,DJ