Increased sensitivity of neonatal mouse myocardia to autonomic transmitters.
Increased sensitivity of neonatal mouse myocardia to autonomic transmitters.
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新生小鼠心肌对自主神经递质的敏感性增加。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
K. Shigenobu
中科院分区：
文献类型：
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作者：
H. Tanaka;S. Manita;K. Shigenobu
在新生和成年小鼠的右房和右室标本上观察了去甲肾上腺素和乙酰胆碱的变时性和变力性反应。去甲肾上腺素和乙酰胆碱在两个年龄段的心房中分别产生正性和负性变时性反应。去甲肾上腺素在两个年龄段的脑室标本中均产生正性变力反应。在所有病例中，以PD2值表示的敏感度在新生儿准备中较高。在脑室，地塞帕明使成人去甲肾上腺素的量效曲线左移，但在新生儿中没有观察到这种移位。新生儿脑室标本对异丙肾上腺素的敏感性高于成人。我们的结果表明，在发育过程中，小鼠心肌对自主神经递质的敏感性降低。至于心室肌对去甲肾上腺素的变力反应，连接前和连接后的机制都是导致发育敏感度下降的原因。
Chronotropic and inotropic responses to noradrenaline and acetylcholine were examined in isolated right atrial and ventricular preparations from neonatal and adult mice. Noradrenaline and acetylcholine produced positive and negative chronotropic responses, respectively, in the atria from both ages. Noradrenaline produced positive inotropic responses in ventricular preparations from both ages. In all cases, the sensitivity, expressed in terms of pD2 values, was higher in neonatal preparations. In the ventricle, desipramine produced a leftward shift of the concentration-response curve for noradrenaline in the adult, but no such shift was observed in the neonate. The sensitivity to isoprenaline of ventricular preparations was higher in the neonate than in the adult. Our results demonstrated developmental decreases in sensitivities to autonomic transmitters in mouse myocardia. As for the inotropic response to noradrenaline of ventricular muscle, both pre- and postjunctional mechanisms were responsible for the developmental decrease in sensitivity.
小鼠心脏中腺苷酸环化酶和β肾上腺素能受体的发育。
DOI：
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发表时间：
1982
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
Chen,FC;Yamamura,HI;Roeske,WR
通讯作者：
Roeske,WR
啮齿动物心脏的手术交感神经切除术及其对激动剂敏感性的影响。
DOI：
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发表时间：
1985
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
Goto,K;Longhurst,PA;Cassis,LA;Head,RJ;Taylor,DA;Rice,PJ;Fleming,WW
通讯作者：
Fleming,WW