One-pot amidation of olefins through Pd-catalyzed coupling of alkylboranes and carbamoyl chlorides.
One-pot amidation of olefins through Pd-catalyzed coupling of alkylboranes and carbamoyl chlorides.
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DOI：
10.1021/jo070724u
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发表时间：
2007-06
期刊：
影响因子：
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通讯作者：
Y. Yasui;Sayo Tsuchida;H. Miyabe;Y. Takemoto
中科院分区：
文献类型：
--
作者：
Y. Yasui;Sayo Tsuchida;H. Miyabe;Y. Takemoto
已经开发出一种以烯烃和氨基甲酰氯为原料的 C1-延长酰胺的一锅法合成方法。烷基硼烷是由末端烯烃与 9-BBN-H 硼氢化生成的，在钯催化剂和 Cs2CO3 存在下与氨基甲酰氯顺利偶联。
A one-pot synthesis of C1-elongated amides starting from olefins and carbamoyl chlorides has been developed. Alkylboranes, generated by hydroboration of terminal olefins with 9-BBN-H, underwent smooth coupling with carbamoyl chlorides in the presence of palladium catalyst and Cs2CO3.