The geoepidemiology of systemic lupus erythematosus
The geoepidemiology of systemic lupus erythematosus
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DOI：
10.1016/j.autrev.2009.12.008
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发表时间：
2010-03-01
影响因子：
13.6
通讯作者：
Gershwin, M. Eric
中科院分区：
文献类型：
--
作者：
Borchers, Andrea T.;Naguwa, Stanley M.;Gershwin, M. Eric
系统性红斑狼疮（SLE）是一种具有多种临床表现和免疫异常的系统性自身免疫性疾病，主要影响女性。尽管目前在很大程度上缺乏关于SLE发病率和流行率的准确数据，但有许多迹象表明，与所有其他种族相比，SLE在欧洲人及其后代中远不常见。该病的临床表现表现出地理或种族差异，欧洲血统患者的病情通常比非洲人、亚洲人、某些“西班牙裔”或混血儿以及各种土著人群轻。特别是，肾脏受累在非欧洲患者中更为常见。遗传因素以及环境、社会人口和社会文化因素都可能导致SLE发病率和临床表现的差异。(C) 2009 Elsevier B.V.版权所有
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with manifold clinical manifestations and immunological abnormalities, affecting primarily women. Although accurate current data on its incidence and prevalence are largely lacking, there are numerous indications that SLE is far less common in Europeans and their descendants compared to all other ethnicities. The clinical manifestations of the disease show geographic or ethnic variation, generally being less severe in patients of European ancestry than in African, Asian, certain "Hispanic" or mestizo, and various indigenous populations. In particular, renal involvement is far more common in non-European patients. Genetic as well as environmental, socio-demographic and sociocultural factors are likely to contribute to the differences in the incidence and clinical expression of SLE. (C) 2009 Elsevier B.V. All rights reserved.