Nasal Nitric Oxide Is Correlated With Nasal Patency and Nasal Symptoms
Nasal Nitric Oxide Is Correlated With Nasal Patency and Nasal Symptoms
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DOI：
10.4168/aair.2019.11.3.367
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发表时间：
2019-05-01
影响因子：
4.4
通讯作者：
Zhang, Luo
中科院分区：
文献类型：
--
作者：
Ren, Lei;Zhang, Wei;Zhang, Luo
目的：一氧化氮（NO）是上、下呼吸系统的重要内源性介质。本研究的目的是探讨中国成年人鼻腔一氧化氮（nNO）正常值范围及其内在影响因素。nNO水平之间的差异鼻炎和无症状的过敏性科目，nNO在变应性鼻炎（AR）的诊断价值进行了进一步调查。根据问卷调查和皮肤点刺试验将参与者分为不同的亚组。在所有这些受试者中，测量nNO、呼出气NO分数（FeNO）和鼻气流阻力。结果：变应性鼻炎患者nNO和FeNO水平均显著高于正常对照组和无症状特应性鼻炎组，差异有统计学意义（P < 0. 05）。无症状特应性受试者的nNO水平显著低于正常成人。非AR患者的FeNO水平显著高于健康和无症状的特应性成人。nNO诊断AR的临界值为117.5 ppb（敏感性50.9%，特异性63.9%）。nNO水平与FeNO水平、75 Pa下测量的总鼻阻力、距前鼻孔0-7 cm范围内的鼻容积（V0- 7 cm）和鼻部症状视觉模拟评分（VAS）评分相关，而FeNO水平与年龄、身高、体重、体表面积、V0- 7 cm范围内的鼻容积和鼻部症状VAS评分相关。鼻变应性鼻炎患者与健康人之间nNO水平存在显著差异，且nNO水平与鼻炎患者的鼻部症状和鼻腔通畅性显著相关。但nNO的临床应用价值尚处于探索阶段。
Purpose: Nitric oxide (NO) is an important endogenous mediator in both upper and lower respiratory systems. The purpose of the present study was to extract nasal NO (nNO) normal range of Chinese adults and the internal influencing factors. The differences in nNO levels between rhinitis and asymptomatic atopic subjects, and the diagnostic value of nNO in allergic rhinitis (AR) were further investigated.Methods: One thousand adults were recruited from the general public. Participants were divided into different subgroups according to the questionnaires and skin prick tests. In all of these subjects, nNO, fractional exhaled NO (FeNO) and nasal airflow resistance were measured. The normal ranges of nNO and FeNO, the differences between subgroups, and the correlations between NO (nNO and FeNO) and other internal factors were analyzed.Results: Both nNO and FeNO levels were significantly higher in AR patients than in healthy and asymptomatic atopic subjects. The nNO levels were significantly lower in asymptomatic atopic subjects than in normal adults. FeNO levels were significantly higher in non-AR patients than in the healthy and asymptomatic atopic adults. The cutoff value of nNO for the diagnosis of AR was 117.5 ppb (sensitivity, 50.9%; specificity, 63.9%). The nNO levels were correlated with FeNO levels, total nasal resistance measured at 75Pa, nasal volume within 0-7 cm from the anterior nares (V0-7cm) and nasal symptom visual analogue scale (VAS) scores, while the FeNO levels were correlated with age, height, weight, body surface area, nasal volume of V0-7cm and the nasal symptom VAS score.Conclusions: The nNO level can be significantly different between healthy and AR patients and may be significantly correlated with nasal symptoms and nasal patency of rhinitis patients. However, the clinical value of nNO is still in the exploration stage.