Selective and sensitive electrochemical detection of glucose in neutral solution using platinum-lead alloy nanoparticle/carbon nanotube nanocomposites
Selective and sensitive electrochemical detection of glucose in neutral solution using platinum-lead alloy nanoparticle/carbon nanotube nanocomposites
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DOI：
10.1016/j.aca.2007.05.047
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发表时间：
2007-07-02
影响因子：
6.2
通讯作者：
Sheu, Fwu-Shan
中科院分区：
文献类型：
--
作者：
Cui, Hui-Fang;Ye, Jian-Shan;Sheu, Fwu-Shan
将Pt-Pb纳米粒子（PtPbNPs）电沉积到多壁碳纳米管（MWCNT）上，得到了一种稳定的PtPbNP/MWCNT纳米复合物，该复合物在中性或碱性介质中对葡萄糖氧化具有较高的电催化活性。更重要的是，具有轻微修改的纳米复合物电极在生理中性pH（保持在负电位）下在安培葡萄糖传感中表现出高灵敏度、高选择性和低检测限。在+0.30 V的中性溶液中，纳米复合电极对11 mM葡萄糖具有良好的线性，灵敏度为17.8 μ RA cm（-2）mM（-1），检测限为1.8 μ M（S/N = 3）。电活性抗坏血酸（0。1 mM）、尿酸（0. 1 mM）和果糖（0.3 mM）分别仅引起3 mM葡萄糖获得的电流响应的23%、14%和9%。在-0.在中性溶液中，电极对葡萄糖的响应线性范围为5 mM，检测限为0。16 mM（S/N = 3），检测灵敏度类似于18 μ A cm（-2）mM（-1）。在该负电位下，抗坏血酸、尿酸和果糖不具有电活性，因此不干扰葡萄糖感测。用Nation涂层修饰纳米复合材料电极，然后在Nation涂覆的PtPbNP/MWCNT纳米复合材料上电沉积第二层PtPbNP，产生葡萄糖传感器（在-0. 15 V），具有较低的检测限（在S/N = 3时为7.0 μ M）和与PtPbNP/MWCNT纳米复合材料相当的灵敏度、选择性和线性。Nation涂层通过降低背景噪声降低了检测限，而第二层PtPbNPs将灵敏度恢复到Nafion涂层之前的水平。(C)2007 Elsevier B. V.保留所有权利。
Electrodeposition of Pt-Pb nanoparticles (PtPbNPs) to multi-walled carbon nanotubes (MWCNTs) resulted in a stable PtPbNP/MWCNT nanocomposite with high electrocatalytic activity to glucose oxidation in either neutral or alkaline medium. More importantly, the nanocomposite electrode with a slight modification exhibited high sensitivity, high selectivity, and low detection limit in amperometric glucose sensing at physiological neutral pH (poised at a negative potential). At +0.30 V in neutral solution, the nanocomposite electrode exhibited linearity up to 11mM of glucose with a sensitivity of 17.8 mu RA cm(-2) mM(-1) and a detection limit of 1.8 mu M (S/N = 3). Electroactive ascorbic acid (0. 1 mM), uric acid (0. 1 mM) and fructose (0.3 mM) invoked only 23%, 14% and 9%, respectively, of the current response obtained for 3 mM glucose. At -0. 15 V in neutral solution, the electrode responded linearly to glucose up to 5 mM with a detection limit of 0. 16 mM (S/N = 3) and detection sensitivity of similar to 18 mu A cm(-2) mM(-1). At this negative potential, ascorbic acid, uric acid, and fructose were not electroactive, therefore, not interfering with glucose sensing. Modification of the nanocomposite electrode with Nation coating followed by electrodeposition of a second layer of PtPbNPs on the Nation coated PtPbNP/MWCNT nanocomposite produced a glucose sensor (poised at -0. 15 V) with a lower detection limit (7.0 mu M at S/N = 3) and comparable sensitivity, selectivity and linearity compared to the PtPbNP/MWCNT nanocomposite. The Nation coating lowered the detection limit by reducing the background noise, while the second layer of PtPbNPs restored the sensitivity to the level before Nafion coating. (C) 2007 Elsevier B.V. All rights reserved.