Dominance and the potential for seasonally balanced polymorphism.
Dominance and the potential for seasonally balanced polymorphism.
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季节性平衡多态性的优势和潜力。
DOI：
10.1101/2023.11.20.567918
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Brud,Evgeny
中科院分区：
文献类型：
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作者：
Brud,Evgeny
基因显性是二倍体基因型适合度的重要组成部分。探索季节性选择下平衡多态性条件的建模者认为，显性反转（其中适应性制度周期性地交替一对等位基因之间的显性方向）是跨越选择强度的广阔空间的双等位基因变异的强大稳定剂。另一种遗传机制，累积超显性（其中健身制度保持恒定的显性方向），已被认为是优先稳定的等位基因特征强选择强度，而需要一个令人难以置信的严格平价弱选择。以前的分析结论通常是在优势参数对称性的假设下得出的。在这里，我调查广义显性计划的二化性人口，以比较这些遗传机制的比例贡献的稳定选择性多态性。特别是，我推导出潜在的多态性（总参数空间赋予稳定性的措施）的广义性别独立模型在四个参数。
Genic dominance is a key component of fitness in diploid genotypes. Modelers exploring the conditions for balanced polymorphism under seasonal selection have argued that a reversal of dominance (where the fitness regime cyclically alternates the direction of dominance between a pair of alleles) is a powerful stabilizer of biallelic variation across a broad space of selection intensities. An alternative genetic mechanism, cumulative overdominance (in which the fitness regime maintains a constant direction of dominance), has been argued to preferentially stabilize alleles characterized by strong selection intensities, while requiring an implausibly strict parity under weak selection. Previous analytical conclusions were typically made under the assumption of symmetries for the dominance parameters. Here I investigate generalized dominance schemes for a bivoltine population in order to compare the proportional contribution of these genetic mechanisms to the stabilization of selective polymorphism. In particular, I derive the potential for polymorphism (a measure of the total parameter space conferring stability) for the generalized sex-independent model in four parameters.