Influence of photosensitizer concentration and polymer composition on photoinduced antimicrobial activity of PVA- and PVA-chitosan-based electrospun nanomaterials cross-linked with tailor-made silicon(IV) phthalocyanine
Influence of photosensitizer concentration and polymer composition on photoinduced antimicrobial activity of PVA- and PVA-chitosan-based electrospun nanomaterials cross-linked with tailor-made silicon(IV) phthalocyanine
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DOI：
10.1007/s43630-022-00229-9
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发表时间：
2022-05
影响因子：
3.1
通讯作者：
A. Galstyan;Konstantin Strokov
中科院分区：
文献类型：
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作者：
A. Galstyan;Konstantin Strokov
根除病原细菌和病毒的持续努力是一项重大努力，需要开发新的创新材料。基于光动力作用的材料代表了一个新兴且有吸引力的研究领域，因此需要对化学设计原理有广泛的了解。在本研究中，我们研究了由通过硅(IV)酞菁衍生物交联的聚乙烯醇或聚乙烯醇-壳聚糖混合物组成的五种不同的纳米纤维膜的抗菌和抗病毒活性，旨在确定载体聚合物和光敏剂浓度对其功效的作用。正如扫描电子显微镜所显示的那样，采用简单的交联过程来创建纤维结构几乎均匀分布的水稳定性材料。抗菌研究的结果表明，聚合物混合物中壳聚糖含量的增加，而不是光敏剂浓度的增加，增强了材料的活性。由于其可见光触发的抗菌活性，所得材料为局部抗菌光动力疗法和环境修复领域提供了宝贵的机会。图形摘要
The ongoing effort to eradicate pathogenic bacteria and viruses is a major endeavor that requires development of new and innovative materials. Materials based on photodynamic action represent an emerging and attractive area of research, and therefore, a broad understanding of chemical design principles is required. In the present study, we investigated the antibacterial and antiviral activities of five different nanofibrous membranes composed of poly(vinyl alcohol) or poly(vinyl alcohol)-chitosan mixture cross-linked through silicon(IV)phthalocyanine derivative with the aim to identify the role of the carrier polymer and photosensitizers concentration on its efficacy. A straightforward cross-linking process was adopted to create a water-stable material with an almost uniform distribution of the fiber structure, as revealed by scanning electron microscopy. The results of the antimicrobial studies showed that the increase in the amount of chitosan in the polymer mixture, rather than the increase in the photosensitizer concentration, enhanced the activity of the material. Due to their visible light-triggered antimicrobial activity, the resulting materials provide valuable opportunities for both topical antimicrobial photodynamic therapy and the area of environmental remediation.Graphical abstract