ANGIOGENESIS - MARKER FOR NEOPLASTIC TRANSFORMATION OF MAMMARY PAPILLARY HYPERPLASIA
ANGIOGENESIS - MARKER FOR NEOPLASTIC TRANSFORMATION OF MAMMARY PAPILLARY HYPERPLASIA
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DOI：
10.1126/science.402692
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
MEDINA, D
中科院分区：
文献类型：
--
作者：
BREM, SS;GULLINO, PM;MEDINA, D
小鼠乳腺乳头状瘤移植到兔虹膜后可诱导新血管形成。这种血管生成能力是癌的一种特性，而不是静止乳腺的特性。在小鼠乳头状增生中，这种特性比癌的任何形态学或临床体征都要早。血管生成能力的测试可能揭示了向临床恶性进展的一个步骤，并可用于筛选活检组织中增生上皮的肿瘤潜能。
Mouse mammary papillomas elicit new formation of vessels when transplanted onto the rabbit iris. This angiogenic capacity is a property of carcinomas but not of the resting mammary gland. In mouse papillary hyperplasia, this property appears earlier than any morphological or clinical sign of carcinoma. A test for angiogenic capacity may reveal a step in the progression toward clinical malignancy and could be used to screen for neoplastic potential of hyperplastic epithelium in biopsy tissues.