Effects of electrode placement on the efficacy of titrated, low-dose ECT.
Effects of electrode placement on the efficacy of titrated, low-dose ECT.
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电极放置对滴定低剂量 ECT 疗效的影响。
DOI：
10.1176/ajp.144.11.1449
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Malitz,S
中科院分区：
文献类型：
--
作者：
Sackeim,HA;Decina,P;Kanzler,M;Kerr,B;Malitz,S
这项双盲、随机分配研究对比了双侧和单侧右侧ECT与低剂量滴定程序的相对疗效。在52例原发性抑郁症患者中，双侧ECT在短期症状减轻方面明显上级单侧右侧ECT。这两种情况在全身性癫痫发作的持续时间或为达到临床缓解而给予的治疗次数方面没有差异。这些发现挑战了这样一种说法，即全身性癫痫发作的诱发本身就足以产生ECT的抗抑郁作用。相反，超过癫痫发作阈值的剂量可能有助于ECT的疗效，特别是单侧右侧电极放置。
This double-blind, random-assignment study contrasted the relative efficacy of bilateral and unilateral right ECT with a low-dose titration procedure. In 52 patients with primary major depressive disorder, bilateral ECT was markedly superior in short-term symptom reduction to unilateral right ECT. The two conditions did not differ in the duration of generalized seizures or in the number of treatments administered to achieve clinical response. The findings challenge the claim that the elicitation of generalized seizure is, in and of itself, sufficient for the antidepressant properties of ECT. Rather, a dose in excess of seizure threshold may contribute to the efficacy of ECT, particularly with a unilateral right electrode placement.