Frequency and prevention of symptomless deep-vein thrombosis in long-haul flights: a randomised trial
Frequency and prevention of symptomless deep-vein thrombosis in long-haul flights: a randomised trial
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DOI：
10.1016/s0140-6736(00)04645-6
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发表时间：
2001-05-12
期刊：
影响因子：
168.9
通讯作者：
Smith, PDC
中科院分区：
文献类型：
--
作者：
Scurr, JH;Machin, SJ;Smith, PDC
背景：长途航空旅行中深静脉血栓形成（DVT）的真实发生率尚不清楚。我们试图确定DVT的频率在下肢在长途经济舱航空旅行和毕业的弹性压缩丝袜在其prevent.Methods的功效，我们招募了89名男性和142名女性乘客超过50岁，没有血栓栓塞的问题。乘客被随机分配到两组中的一组：一组穿着I级膝下渐变弹性压缩袜，另一组没有。所有乘客每次飞行持续时间超过8小时（平均总持续时间为24小时），并在6周内返回英国。双功超声检查用于评估旅行前后的深静脉。分析血液样本中两个特定的常见基因突变，因子V莱顿（NL）和凝血酶原G20210 A（PGM），这两个基因突变易患静脉血栓栓塞。结果116名乘客中有12名（10%; 95%CI 4.8-16.0%）在小腿（5名男性）发生了无血管性DVT。七个女人）。这些乘客中没有人穿弹性压缩袜，两人是FVL杂合子。另外4名患者穿着弹性压缩袜，患有静脉曲张并发生血栓性浅静脉炎。其中一名乘客是FVL和PGM的杂合子。没有一个乘客穿着I类压缩丝袜发展DVT（95%CI 0-3.2%）。解释我们的结论是，无袖DVT可能发生在10%的长途航空旅客。在长途航空旅行中穿着弹性压缩袜与无袖深静脉血栓的减少有关。
Background The true frequency of deep-vein thrombosis (DVT) during long-haul air travel is unknown. We sought to determine the frequency of DVT in the lower limb during long-haul economy-class air travel and the efficacy of graduated elastic compression stockings in its prevention.Methods We recruited 89 male and 142 female passengers over 50 years of age with no history of thromboembolic problems. Passengers were randomly allocated to one of two groups: one group wore class-I below-knee graduated elastic compression stockings, the other group did not. All the passengers made journeys lasting more than 8 h per flight (median total duration 24 h), returning to the UK within 6 weeks. Duplex ultrasonography was used to assess the deep veins before and after travel. Blood samples were analysed for two specific common gene mutations, factor V Leiden (NL) and prothrombin G20210A (PGM), which predispose to venous thromboembolism. A sensitive D-dimer assay was used to screen for the development of recent thrombosis.Findings 12/116 passengers (10%; 95% CI 4.8-16.0%) developed symptomless DVT in the calf (five men. seven women). None of these passengers wore elastic compression stockings, and two were heterozygous for FVL. Four further patients who wore elastic compression stockings, had varicose veins and developed superficial thrombophlebitis. One of these passengers was heterozygous for both FVL and PGM. None of the passengers who wore class-I compression stockings developed DVT (95% CI 0-3.2%).Interpretation We conclude that symptomless DVT might occur in up to 10% of long-haul airline travellers. Wearing of elastic compression stockings during long-haul air travel is associated with a reduction in symptomless DVT.