Expression pattern and cellular sources of chemokines in primary central nervous system lymphoma
Expression pattern and cellular sources of chemokines in primary central nervous system lymphoma
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DOI：
10.1007/s00401-007-0258-x
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发表时间：
2007-09-01
影响因子：
12.7
通讯作者：
Deckert, Martina
中科院分区：
文献类型：
--
作者：
Brunn, Anna;Montesinos-Rongen, Manuel;Deckert, Martina
研究了原发性中枢神经系统淋巴瘤（PCNSL）中一组趋化因子及其相应受体的表达模式。肿瘤细胞在mRNA和蛋白水平上一致地表达CXCR 4、CXCL 12、CXCR 5和CXCL 13。脑内皮细胞呈CXCL12和CXCL13阳性，而反应性星形胶质细胞和小胶质细胞表达CXCL12、CCR5和CCR6。PCNSL中的炎性T细胞以CCR5和CCR6阳性为特征。两者合计，我们的数据表明，细胞类型特异性的剧目的趋化因子和趋化因子受体的表达PCNSL表明，趋化因子介导的相互作用，促进跨越血脑屏障以及PCNSL细胞的脑内传播。此外，肿瘤细胞表达的趋化因子可能有助于诱导反应性胶质细胞的变化，并影响PCNSL中炎性浸润的组成。因此，不同趋化因子谱的细胞类型特异性表达可能在PCNSL的发病机制中起作用，并可能有助于其特征性组织学外观。
The expression pattern of a subset of chemokines and their corresponding receptors was investigated in primary central nervous system lymphomas (PCNSL). The tumor cells consistently expressed CXCR4, CXCL12, CXCR5, and CXCL13, both at mRNA and protein levels. Cerebral endothelial cells were positive for CXCL12 and CXCL13, while reactive astrocytes and microglial cells expressed CXCL12, CCR5, and CCR6. Inflammatory T cells in PCNSL were characterized by CCR5 and CCR6 positivity. Taken together, our data indicate a cell type-specific repertoire of chemokine and chemokine receptor expression in PCNSL suggesting that chemokine-mediated interactions facilitate crossing of the blood-brain barrier as well as intracerebral dissemination of PCNSL cells. In addition, chemokines expressed by tumor cells may contribute to induction of reactive glial changes and influence the composition of inflammatory infiltrates in PCNSL. Therefore, cell type specific expression of distinct chemokine profiles likely plays a role in the pathogenesis of PCNSL and may contribute to their characteristic histological appearance.