Progress, challenges, and new opportunities for the prevention of mother-to-child transmission of HIV under the US President's Emergency Plan for AIDS Relief.
Progress, challenges, and new opportunities for the prevention of mother-to-child transmission of HIV under the US President's Emergency Plan for AIDS Relief.
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DOI：
10.1097/qai.0b013e31825f3284
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发表时间：
2012-08-15
期刊：
影响因子：
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通讯作者：
Stringer JS
中科院分区：
文献类型：
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作者：
Chi BH;Adler MR;Bolu O;Mbori-Ngacha D;Ekouevi DK;Gieselman A;Chipato T;Luo C;Phelps BR;McClure C;Mofenson LM;Stringer JS
2011年6月，联合国艾滋病毒/艾滋病联合规划署、美国总统艾滋病紧急救援计划（PEPFAR）和其他合作者概述了一项在全球范围内几乎消除儿童艾滋病的变革计划。该倡议的宏伟目标包括到2015年将儿童艾滋病毒新发感染率降低90%，将艾滋病毒相关孕产妇死亡率降低50%。总统艾滋病紧急救援计划作出了前所未有的承诺，在全球范围内扩大和改善预防母婴传播艾滋病毒的服务，预计将在实现实际消除艾滋病毒的目标方面发挥关键作用。迄今为止，总统艾滋病紧急救援计划在许多国家方案的成功中发挥了重要作用，包括扩大了防止母婴传播服务的覆盖面，加强了防止母婴传播与艾滋病毒护理和治疗之间的连续护理，提供了更有效的抗逆转录病毒预防疗法，设计了创新但简化的防止母婴传播方法，以及制定了评估方案有效性的新战略。这些成就是通过与东道国政府、联合国机构、其他捐助者（如全球艾滋病、结核病和疟疾基金）、非政府组织和私营部门伙伴的合作努力取得的。为了成功实现预防新的婴儿艾滋病毒感染的雄心勃勃的全球目标，总统艾滋病紧急救援计划必须继续利用现有的防止母婴传播平台，同时制定创新方法，迅速扩大高质量的艾滋病毒服务。总统艾滋病紧急救援计划还必须谨慎地将防止母婴传播纳入更广泛的艾滋病毒综合预防议程，以便在全世界实现“无艾滋病的一代”方面取得真实的进展。
In June 2011, the Joint United Nations Programme on HIV/AIDS, the US President’s Emergency Plan for AIDS Relief (PEPFAR), and other collaborators outlined a transformative plan to virtually eliminate pediatric AIDS worldwide. The ambitious targets of this initiative included a 90% reduction in new pediatric HIV infections and a 50% reduction in HIV-related maternal mortality—all by 2015. PEPFAR has made an unprecedented commitment to the expansion and improvement of prevention of mother-to-child HIV transmission (PMTCT) services globally and is expected to play a critical role in reaching the virtual elimination target. To date, PEPFAR has been instrumental in the success of many national programs, including expanded coverage of PMTCT services, an enhanced continuum of care between PMTCT and HIV care and treatment, provision of more efficacious regimens for antiretroviral prophylaxis, design of innovative but simplified PMTCT approaches, and development of new strategies to evaluate program effectiveness. These accomplishments have been made through collaborative efforts with host governments, United Nations agencies, other donors (eg, the Global Fund for AIDS, Tuberculosis, and Malaria), nongovernmental organizations, and private sector partners. To successfully meet the ambitious global targets to prevent new infant HIV infections, PEPFAR must continue to leverage the existing PMTCT platform, while developing innovative approaches to rapidly expand quality HIV services. PEPFAR must also carefully integrate PMTCT into the broader combination prevention agenda for HIV, so that real progress can be made toward an “AIDS-free generation” worldwide.