Multiple non-auditory cortical regions innervate the auditory midbrain
Multiple non-auditory cortical regions innervate the auditory midbrain
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多个非听觉皮层区域支配听觉中脑
DOI：
10.1101/627232
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Olthof B
中科院分区：
文献类型：
--
作者：
Olthof B
我们对声音的感知体验依赖于多个感官和认知领域的整合，然而，支持这种整合的网络尚不清楚。连接不同的皮质域已经被描述，但我们不知道在多大程度上连接也存在于多个皮质域和皮质下结构之间。在成年雄性大鼠（褐家鼠）的逆行追踪显示，下丘，听觉中脑，接收密集的下行预测不仅，如前所述，从听觉皮层，但也从视觉，体感，运动，和前额叶皮质。虽然所有这些下行连接都是双侧的，但感觉区的连接比运动区和前额叶皮层的连接表现出更明显的同侧优势。逆行追踪确定的皮质区顺行示踪剂注射证实了这些发现，并显示皮质纤维终止于下丘的所有三个分区。免疫标记显示，皮质终末靶向GABA能抑制性神经元和假定的GABA能兴奋性神经元。这些研究结果表明，听觉感知和行为是由一个网络，包括广泛的下行连接到中脑从感觉，行为，和executive cortex.Significance statement意义的声明，使我们听到的不仅取决于声音的分析，但也从其他感官的信息与大脑的预测有关的属性和意义的声音。先前的研究表明，感官和高级认知中心的预测之间的相互作用发生在大脑皮层内。通过追踪大鼠的神经连接，我们发现，下丘，皮层下，中脑听觉中心，接受广泛的连接，从大脑皮层的视觉，触觉，运动和认知功能，除了代表听觉的区域。这些研究结果表明，广泛的皮层反馈在听觉通路的早期阶段比以前认识到的。
Our perceptual experience of sound depends on the integration of multiple sensory and cognitive domains, however the networks subserving this integration are unclear. Connections linking different cortical domains have been described, but we do not know the extent to which connections also exist between multiple cortical domains and subcortical structures. Retrograde tracing in adult male rats (Rattus norvegicus) revealed that the inferior colliculus, the auditory midbrain, receives dense descending projections not only, as previously established, from the auditory cortex, but also from the visual, somatosensory, motor, and prefrontal cortices. While all these descending connections are bilateral, those from sensory areas show a more pronounced ipsilateral dominance than those from motor and prefrontal cortices. Injections of anterograde tracers into the cortical areas identified by retrograde tracing confirmed those findings and revealed cortical fibers terminating in all three subdivisions of the inferior colliculus. Immunolabeling showed that cortical terminals target both GABAergic inhibitory, and putative glutamatergic excitatory neurons. These findings demonstrate that auditory perception and behavior are served by a network that includes extensive descending connections to the midbrain from sensory, behavioral, and executive cortices.SIGNIFICANCE STATEMENTMaking sense of what we hear depends not only on the analysis of sound, but also on information from other senses together with the brain's predictions about the properties and significance of the sound. Previous work suggested that this interplay between the senses and the predictions from higher cognitive centers occurs within the cerebral cortex. By tracing neural connections in rat, we show that the inferior colliculus, the subcortical, midbrain center for hearing, receives extensive connections from areas of the cerebral cortex concerned with vision, touch, movement, and cognitive function, in addition to areas representing hearing. These findings demonstrate that wide-ranging cortical feedback operates at an earlier stage of the hearing pathway than previously recognized.