Richard Dickerson, Molecular Clocks, and Rates of Protein Evolution
Richard Dickerson, Molecular Clocks, and Rates of Protein Evolution
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DOI：
10.1007/s00239-020-09973-x
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发表时间：
2020-11-18
影响因子：
3.9
通讯作者：
Alvarez-Ponce, David
中科院分区：
文献类型：
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作者：
Alvarez-Ponce, David
蛋白质的行为近似于分子钟，以或多或少的恒定速率积累氨基酸替换。尽管如此，每种蛋白质都显示出特有的进化速度：有些蛋白质在很长一段时间内基本保持不变，而另一些蛋白质则可以迅速积累氨基酸替换。理查德·迪克森（Richard Dickerson）在《分子进化杂志》（Journal of Molecular Evolution）第一期上发表的一篇文章（J Mol Evol 1：26-45，1971）描述了第一次分析，其中比较了许多蛋白质的进化速率，并根据它们的功能解释了差异。当比较不同物种的纤维蛋白肽、血红蛋白和细胞色素c的序列时，他观察到氨基酸替换的数量与发散时间之间存在线性关系。值得注意的是，纤维蛋白肽进化得很快，细胞色素c进化得很慢，血红蛋白的进化速度居中。在《分子进化杂志》（Journal of Molecular Evolution）庆祝创刊50周年之际，我特别强调这篇具有里程碑意义的文章，并反思它对分子进化领域的影响。
Proteins approximately behave as molecular clocks, accumulating amino acid replacements at a more or less constant rate. Nonetheless, each protein displays a characteristic rate of evolution: whereas some proteins remain largely unaltered over large periods of time, others can rapidly accumulate amino acid replacements. An article by Richard Dickerson, published in the first issue of the Journal of Molecular Evolution (J Mol Evol 1:26-45, 1971), described the first analysis in which the rates of evolution of many proteins were compared, and the differences were interpreted in the light of their function. When comparing the sequences of fibrinopeptides, hemoglobin, and cytochrome c of different species, he observed a linear relationship between the number of amino acid replacements and divergence time. Remarkably, fibrinopeptides had evolved fast, cytochrome c had evolved slowly, and hemoglobin exhibited an intermediate rate of evolution. As the Journal of Molecular Evolution celebrates its 50th anniversary, I highlight this landmark article and reflect on its impact on the field of Molecular Evolution.