Secretory phospholipase A2
Secretory phospholipase A2
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DOI：
10.1248/bpb.27.1158
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发表时间：
2004-08-01
影响因子：
2
通讯作者：
Kudo, I
中科院分区：
文献类型：
--
作者：
Murakami, M;Kudo, I
分泌型磷脂酶A(2)(Spla(2))是一个结构相关、富含二硫键、低分子量、具有His-Asp催化二聚体的脂解酶家族。Spla(2)S广泛分布于脊椎动物和无脊椎动物、植物、细菌和病毒中，哺乳动物中有10种具有催化活性的Spla(2)同工酶。虽然哺乳动物Spla(2)S的结构基础已经被很好地记录下来，但它们的生理功能仍然是有争议的。哺乳动物Spla(2)S具有不同的酶性质和不同的组织表达模式，这表明在体内，每种酶作用于不同的磷脂膜部分。本文根据Spla(2)S对哺乳动物和非哺乳动物细胞膜的不同作用，简要综述了我们对其可能的生理功能的最新认识。
Secretory phospholipase A(2) (sPLA(2)) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad. sPLA(2)s are distributed in a wide variety of vertebrate and invertebrate animals, plants, bacteria, and viruses, and there are 10 catalytically active sPLA(2) isozymes in mammals. Although the structural bases for mammalian sPLA(2)s have been well documented, their physiological functions are still subject to debate. Individual mammalian sPLA(2)s have distinct enzymatic properties and display distinct tissue expression patterns, suggesting that each enzyme acts on distinct phospholipid membrane moieties in vivo. In this article, we briefly review our latest understanding of the possible physiological functions of sPLA(2)s, in keeping with their diverse actions on mammalian and nonmammalian cell membranes.