Canalicular bile production in dogs.
Canalicular bile production in dogs.
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狗的小管胆汁产生。
DOI：
10.1152/ajplegacy.1968.214.4.866
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
S. Bradley
中科院分区：
文献类型：
--
作者：
H. O. Wheeler;E. Ross;S. Bradley
WHEELERJENRY ~.、伊丽莎白·D·罗斯和斯坦利·E·布拉德利。狗的小管胆汁产生。是。 J.生理学。 2 14(4)：866-874。 1968.-在三只配备托马斯十二指肠插管的未麻醉胆囊切除犬中测量了 14C 标记的肌酐、赤藓糖醇、菊粉、甘露醇、蔗糖和尿素的胆汁清除率。以不同的速率静脉注射牛磺胆酸钠，以产生胆汁流量的变化。甘露醇的清除率与胆汁酸分泌率呈线性变化，并且在大多数情况下高于胆汁流量。肌酐、赤藓糖醇和尿素的清除率与甘露醇清除率相似，只是在三只狗中的一只中赤藓糖醇清除率略高于甘露醇清除率。胆汁与血浆的浓度比通常大于 1，并且在胆汁酸分泌率较低时最高。菊粉和蔗糖的清除率非常低。促泌素利胆对甘露醇清除率没有影响。这些数据表明，甘露醇和赤藓糖醇等化合物的清除率可以估计狗体内的小管胆汁流量。虽然小管流量与胆汁酸分泌率线性相关，但小管胆汁产生似乎存在独立的基础速率。狗体内的胆管或胆管液体重吸收使小管胆汁浓缩了三倍。
WHEELERJENRY ~.,ELIZABETH D.Ross, AND STANLEY E. BRADLEY. Canalicular bile production in dogs. Am. J. Physiol. 2 14(4) : 866-874. 1968.-Biliary clearances of 14C-labeled creatinine, erythritol, inulin, mannitol, sucrose, and urea were measured in three unanesthetized cholecystectomized dogs equipped with Thomas duodenal cannulas. Sodium taurocholate was infused intravenously at varying rates to produce changes in bile flow. Clearance of mannitol varied linearly with bile acid secretion rate and in most cases was higher than bile flow. Clearances of creatinine, erythritol, and urea were similar to mannitol clearance except that erythritol clearance was slightly higher than mannitol clearance in one of the three dogs. Bile-to-plasma concentration ratios were usually greater than one and were highest at low rates of bile acid secretion. Inulin and sucrose clearances were very low. Secretin choleresis had no effect on mannitol clearance. These data suggest that clearances of compounds such as mannitol and erythritol provide an estimate of canalicular bile flow in the dog. While canalicular flow is linearly related to bile acid secretion rate, there appears to be an independent basal rate of canalicular bile production. Canalicular bile is concentrated as much as threefold by ductal or ductular fluid reabsorption in the dog.