A novel link between SUMO modification and cancer metastasis
A novel link between SUMO modification and cancer metastasis
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DOI：
10.4161/cc.5.14.3008
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发表时间：
2006-07-15
期刊：
影响因子：
4.3
通讯作者：
Baek, Sung Hee
中科院分区：
文献类型：
--
作者：
Baek, Sung Hee
SUMO（small ubiquitin-related modifiers）是泛素样蛋白的一个成员，它修饰大量的转录因子和辅调节因子。虽然泛素和SUMO表现出结构相似性，但SUMO化的生物输出与主要由泛素化介导的蛋白质降解有些不同。SUMO化参与调节转录辅因子和染色质重塑因子的亚细胞定位和稳定。鉴于许多癌基因和抑癌基因已被确定为SUMO化的靶点，对蛋白质SUMO化的研究可能有助于阐明肿瘤发生和转移的机制。染色质重塑复合物SUMO化的新作用已经被阐明。Reptin染色质重塑复合物的SUMO化状态调节KAI 1转移抑制基因和具有转移潜力的癌细胞的侵袭活性;这揭示了SUMO修饰与癌症转移之间的新联系。在这里，我概述了这些发现，并讨论蛋白SUMO化在癌症转移中的生物学意义。
SUMO (small ubiquitin-related modifier), a member of ubiquitin-like proteins, modifies a large number of transcription factors and coregulators. Although ubiquitin and SUMO exhibit structural similarities, the biological output of SUMOylation is somewhat distinct from protein degradation that is mainly mediated by ubiquitination. SUMOylation is involved in the regulation of the subcellular localization and stabilization of transcriptional cofactors and chromatin remodeling factors. Given the number of oncogenes and tumor suppressor genes that have been defined as targets for SUMOylation, studies on protein SUMOylation may shed light on the mechanism of tumorigenesis and metastasis. New roles of SUMOylation of a chromatin-remodeling complex have been elucidated. The SUMOylation status of the reptin chromatin-remodeling complex modulates the KAI1 metastasis suppressor gene and the invasive activity of cancer cells with metastatic potential; this revealed a novel link between SUMO modification and cancer metastasis. Here I overview these findings and discuss biological importance of protein SUMOylation in cancer metastasis.