A standardized method for the evaluation of respiratory muscle endurance in patients with Duchenne muscular dystrophy
A standardized method for the evaluation of respiratory muscle endurance in patients with Duchenne muscular dystrophy
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DOI：
10.1016/s0960-8966(00)00179-6
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发表时间：
2001-03-01
影响因子：
2.8
通讯作者：
Ramonatxo, M
中科院分区：
文献类型：
--
作者：
Matecki, S;Topin, N;Ramonatxo, M
该研究的目的是开发一种标准化方法，使用受控呼吸来量化杜氏肌营养不良症 (DMD) 儿童的呼吸肌耐力，并测试其可重复性。在 10 名 DMD 患者中，所有患者年龄都在 10 至 14 岁之间（平均年龄为 11.5 +/- 1.5 岁），除了两名 20 岁和 22 岁的患者以及 10 名健康儿童（平均年龄为 12 +/- 1 岁）外，我们测量固定在个体最大吸气压力 (Pi(max)) 35% 的阈值负荷可耐受的最长时间 (T-lim)。我们要求孩子们利用视觉反馈和听觉信号保持休息呼吸模式，直到精疲力竭。 DMD 儿童的平均 T-lim 为 4.45 +/- 1.45 分钟，并且值具有可重复性。所有健康儿童都能获得大于 30 分钟的 T-lim 值。 DMD 儿童的呼吸肌比健康受试者更容易疲劳。该方法对于评估治疗效果以及对没有明显学习障碍的 DMD 患者呼吸肌的具体训练应该是令人满意的。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
The aim of the study was to develop a standardized method using controlled breathing to quantify respiratory muscle endurance in children with Duchenne muscular dystrophy (DMD) and to test its reproducibility, In 10 DMD patients, all between 10 and 14 years (mean age, 11.5 +/- 1.5 years), except for two patients of 20 and 22 years, and 10 healthy children (mean age, 12 +/- 1 years), we measured the maximal time (T-lim) that a threshold load fixed at 35% of the individual maximal inspiratory pressure (Pi(max)) could be tolerated. We asked the children to maintain their rest breathing pattern until exhaustion using visual feedback and an auditory signal. The mean T-lim in the DMD children was 4.45 +/- 1.45 min and values were reproducible. All healthy children were able to obtain T-lim values greater than 30 min. The respiratory muscles of DMD children are more susceptible to fatigue than those of healthy subjects. This method should be satisfactory for estimating the effect of treatment and for the specific training of respiratory muscles in DMD patients without significant learning disability. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.