If in non-pacemaker cells:: Role and pharmacological implications
If in non-pacemaker cells:: Role and pharmacological implications
复制标题
DOI：
10.1016/j.phrs.2006.03.015
复制
发表时间：
2006-05-01
影响因子：
9.3
通讯作者：
Mugelli, Alessandro
中科院分区：
文献类型：
--
作者：
Cerbai, Elisabetta;Mugelli, Alessandro
起搏通道在产生窦房节律活动中起主要作用。然而，它们的表达并不局限于专门的心肌细胞，如主要和辅助起搏器。过去十年收集的电生理和分子数据表明，f-通道也存在于非起搏器心肌细胞中，并在心脏肥大和衰竭时上调。f-通道的错误定位表达和/或过度表达是电生理重构的结果，并且从临床角度来看，可能代表心力衰竭中的致瘤机制，心力衰竭是与心脏性猝死的高风险相关的病症。I-f的潜在促炎作用和选择性f通道阻断剂的可用性使I-f成为心脏病的合适治疗靶点。(c)2006爱思唯尔有限公司保留所有权利。
Pacemaker channels play a major role in the generation of sinoatrial rhythmic activity. However, their expression is not confined to specialized myocardial cells, such as primary and subsidiary pacemakers. Electrophysiological and molecular data collected over the last ten years have demonstrated that f-channels are also present in non-pacemaker cardiomyocytes, and become upregulated in cardiac hypertrophy and failure. Mislocalized expression and/or overexpression of f-channels are a consequence of electrophysiological remodeling and, from a clinical point of view, may represent an arrhythmogenic mechanism in heart failure, a condition associated with a high risk for sudden cardiac death. The potential arrhythmogenic role of I-f and the availability of selective f-channel blockers cause I-f to be a suitable therapeutic target in heart disease. (c) 2006 Elsevier Ltd. All rights reserved.