Dietary phosphorus restriction reverses the impaired bone mineralization in vitamin D receptor knockout mice.
Dietary phosphorus restriction reverses the impaired bone mineralization in vitamin D receptor knockout mice.
复制标题
膳食磷限制可逆转维生素 D 受体敲除小鼠受损的骨矿化。
作者：
R. Masuyama;Y. Nakaya;S. Tanaka;H. Tsurukami;T. Nakamura;S. Watanabe;T. Yoshizawa;S. Kato;K. Suzuki
钙稳态所需的维生素D缺乏，会导致佝偻病伴低钙血症和低磷血症，导致生长迟缓和骨形成受损。缺乏维生素D受体（VDR）的小鼠会出现佝偻病的典型特征，这表明VDR在控制维生素D的作用中起着重要作用。据报道，在喂食补充有高浓度钙（2%）和磷（1.25%）的饮食的VDR KO小鼠中，受损的矿物质稳态的正常化也可逆转骨畸形和生长迟缓。然而，磷和钙的动员与维生素D作用的核控制之间的关系仍不清楚。本研究旨在探讨日粮磷对骨矿物质动员和骨矿化的影响。我们在此报告称，喂食补充有限量磷（0.25%）和正常量钙（0.5%）的饮食4周可逆转VDR KO小鼠的生长迟缓和矿化受损，高钙和高磷饮食也是如此（Ca：2%; P：1.25%）。因此，本研究表明，钙和磷的动员是通过维生素D依赖性和非依赖性系统的差异调节，钙和磷的摄入量在适当的比例是重要的矿物质稳态和骨矿化。
Deficiency of vitamin D, which is required for calcium homeostasis, causes rickets with hypocalcemia and hypophosphatemia, resulting in growth retardation and impaired bone formation. Mice lacking the vitamin D receptor (VDR) develop the typical features of rickets, establishing that VDR plays a role in controlling the actions of vitamin D. Normalization of impaired mineral homeostasis in VDR KO mice fed a diet supplemented with high concentrations of calcium (2%) and phosphorus (1.25%) is reported to reverse the malformation of bone and the growth retardation as well. However, the relationship between mobilization of phosphorus and calcium and nuclear control of vitamin D actions remains unclear. The present study was undertaken to determine the effect of dietary phosphorus on mineral mobilization and bone mineralization. We report here that feeding a diet supplemented with a restricted amount of phosphorus (0.25%) and a normal amount of calcium (0.5%) for 4 weeks reverses the growth retardation and the impaired mineralization in VDR KO mice, as does a high-calcium and high-phosphorus diet (Ca: 2%; P: 1.25%). Thus, the present study suggests that mobilization of calcium and mobilization of phosphorus are differentially regulated through vitamin D-dependent and -independent systems, and that intake of calcium and phosphorus in the proper ratio is important for mineral homeostasis and bone mineralization.