Detection threshold for inspiratory resistive loads and respiratory-related evoked potentials
Detection threshold for inspiratory resistive loads and respiratory-related evoked potentials
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DOI：
10.1152/japplphysiol.01436.2005
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Chou, Yang-Ling
中科院分区：
文献类型：
--
作者：
Davenport, Paul W.;Chan, Pei-Ying Sarah;Chou, Yang-Ling
吸气性负荷检测阈值与呼吸相关诱发电位（RREP）峰值之间的关系尚不清楚。假设RREP的短潜伏期和长潜伏期峰值仅在吸气负荷超过检测阈值时才会引起。吸气阻力负荷的检测阈值是在有吸气中断或开始负荷表现的健康受试者中测量的。在一个单独的协议中，rrep被记录为跨越检测阈值的电阻性负载。这些负荷分别在刺激参加和忽略两个阶段进行。开始和中断负载表现具有相同的电阻负载检测阈值。在参与和忽略两种情况下，当负载超过检测阈值时，观察到RREP的P-1、N-f和N-1峰。P-300只有在出席的情况下才会出现负载超过检测阈值的情况。在阈值负荷下，没有RREP成分被激发。P-1、N-f和P-300的振幅随电阻性负载的大小而变化。研究结果支持了电阻性负载阈值诱发rrep的假设。RREP峰值的幅值随负载大小的变化而变化。认知P-300 RREP峰值仅存在于可检测的负荷和受试者注意刺激时。负荷低于检测阈值时RREP的缺失和负荷超过检测阈值时RREP的存在与呼吸机械感觉信息加工的神经测量门控一致。
The relationship between detection threshold of inspiratory resistive loads and the peaks of the respiratory-related evoked potential ( RREP) is unknown. It was hypothesized that the short-latency and long- latency peaks of the RREP would only be elicited by inspiratory loads that exceeded the detection threshold. The detection threshold for inspiratory resistive loads was measured in healthy subjects with inspiratory-interruption or onset load presentations. In a separate protocol, the RREPs were recorded with resistive loads that spanned the detection threshold. The loads were presented in stimulus attend and ignore sessions. Onset and interruption load presentations had the same resistive load detection threshold. The P-1, N-f, and N-1 peaks of the RREP were observed with loads that exceeded the detection threshold in both attend and ignore conditions. The P-300 was present with loads that exceeded the detection threshold only in the attend condition. No RREP components were elicited with subthreshold loads. The P-1, N-f, and P-300 amplitudes varied with resistive load magnitude. The results support the hypothesis that there is a resistive load threshold for eliciting the RREPs. The amplitude of the RREP peaks vary as a function of load magnitude. The cognitive P-300 RREP peak is present only for detectable loads and when the subject attends to the stimulus. The absence of the RREP with loads below the detection threshold and the presence of the RREP elicited by suprathreshold loads are consistent with the gating of these neural measures of respiratory mechanosensory information processing.