Introductions and early spread of SARS-CoV-2 in the New York City area
Introductions and early spread of SARS-CoV-2 in the New York City area
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DOI：
10.1126/science.abc1917
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发表时间：
2020-07-17
期刊：
影响因子：
56.9
通讯作者：
van Bakel, Harm
中科院分区：
文献类型：
--
作者：
Gonzalez-Reiche, Ana S.;Hernandez, Matthew M.;van Bakel, Harm
纽约市（NYC）已成为当前严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行的中心之一。为了确定病毒在纽约大都市区快速传播的早期传播事件，我们对在西奈山卫生系统寻求治疗的患者中导致2019年冠状病毒病（COVID-19）的病毒进行了测序。对84个不同SARS-CoV-2基因组的系统发育分析表明，主要从欧洲和美国其他地区引入了多个独立但孤立的引入。此外，我们发现了SARS-CoV-2社区传播的证据，这是由居住在城市不同社区的患者中发现的相关病毒簇所提出的。
New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.