Positive Expression of LSD1 and Negative Expression of E-cadherin Correlate with Metastasis and Poor Prognosis of Colon Cancer
Positive Expression of LSD1 and Negative Expression of E-cadherin Correlate with Metastasis and Poor Prognosis of Colon Cancer
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DOI：
10.1007/s10620-012-2552-2
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发表时间：
2013-06-01
影响因子：
3.1
通讯作者：
Zeng Liang
中科院分区：
文献类型：
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作者：
Ding Jie;Zhang Zhongmin;Zeng Liang
目的研究LSD1、E-钙粘蛋白和N-钙粘蛋白在结肠癌组织中的表达及其临床意义。方法采用免疫组织化学方法检测LSD1、E-钙粘蛋白和N-钙粘蛋白在结肠癌组织中的表达，并分析其与临床病理特征的关系。结果LSD1、E-钙粘蛋白和N-钙粘蛋白在结肠癌组织中的阳性表达分别为66.7%(72/108)和66.7%(72/108)。85.2%(92/108)和41.7%(45/108)。在高TNM分期和有远处转移的结肠癌组织中，LSD1的表达显著升高(P<；0.05)。进一步分析表明，LSD1的表达与淋巴结转移和远处转移呈正相关(P<；0.05)。在高TNM分期和有远处转移的结肠癌组织中，E-钙粘蛋白的表达显著下调(P<；0.05)，而N-钙粘蛋白的表达在不同的临床和病理特征中无显著差异(P>；0.05)。相关分析显示，LSD1表达与E-钙粘蛋白表达呈负相关(r(S)=-0.318，P=0.001)，与N-钙粘蛋白表达无明显相关性(r(S)=0.182，P=0.06)。结论LSD1在高TNM分期和远处转移的结肠癌组织中的表达显著高于E-钙粘蛋白的表达，而E-钙粘蛋白的表达明显低于LSD1的表达。LSD1阳性表达和E-钙粘附素阴性表达可能是结肠癌预后不良的预测因素。
Background The first identified lysine-specific demethylase, LSD1, plays an important role in the metastatic progression of several types of cancer.Aims The aim of this study was to investigate LSD1, E-cadherin, and N-cadherin expression in colon cancer specimens and their clinical significance.Methods The expression of LSD1, E-cadherin, and N-cadherin in colon cancer specimens was determined by immunohistochemistry, and the relationship between the expression of the respective molecules and clinicopathological characteristics was analyzed.Results The positive expression rates of LSD1, E-cadherin, and N-cadherin in colon cancer specimens were 66.7 % (72/108), 85.2 % (92/108), and 41.7 % (45/108), respectively. LSD1 was significantly more highly expressed in colon cancer specimens classified as high TNM stage lesions and with distant metastasis (P < 0.05). Further analysis demonstrated that LSD1 expression was positively correlated with lymph node and distant metastases (P < 0.05). However, E-cadherin expression was significantly downregulated in colon cancer specimens classified as high TNM stage lesions and with distant metastasis (P < 0.05), whereas the expression of N-cadherin did not differ significantly according to clinical and pathological characteristics (P > 0.05). Correlation analysis revealed that LSD1 expression was negatively correlated with E-cadherin expression (r(s) = -0.318, P = 0.001), but not evidently correlated with N-cadherin expression (r(s) = 0.182, P = 0.06). Colon cancer specimens with positive LSD1 expression and negative E-cadherin expression were correlated with significantly lower overall survival.Conclusions LSD1 showed a significantly higher expression, in contrast to the significantly lower expression of E-cadherin, in colon cancer specimens classified as high TNM stage lesions and with distant metastasis. Positive expression of LSD1 and negative expression of E-cadherin may be predictors of a worse colon cancer prognosis.