Age-Related Differences in Episodic Memory: A Synergistic Contribution of Genetic and Physiological Vascular Risk Factors
Age-Related Differences in Episodic Memory: A Synergistic Contribution of Genetic and Physiological Vascular Risk Factors
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DOI：
10.1037/a0028669
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发表时间：
2012-07-01
期刊：
影响因子：
2.4
通讯作者：
Raz, Naftali
中科院分区：
文献类型：
--
作者：
Bender, Andrew R.;Raz, Naftali
目的：血管风险与年龄敏感性认知功能障碍有关。然而，年龄相关的血管风险和认知功能的差异可以部分解释为遗传因素，如载脂蛋白E（APOE）基因的等位基因的存在。虽然这些因素与认知缺陷之间的联系经常被报道，但它们对健康成年人的联合影响很少被调查。我们假设，血管风险的表型指标（脉压增加和高血胆固醇水平）和遗传（APOE β 4等位基因）风险因素将对健康而不是典型成年人的情景记忆产生协同的负面影响。方法：我们测量了血压，血胆固醇水平，识别记忆，和自由回忆的寿命样本血压正常的成年人18-77岁。从口腔培养物中确定APOE基因型。结果如下：一般线性模型分析显示，脉压升高与记忆力下降相关，但仅在携带APOE等位基因-APOE状态x PP相互作用的携带者中，F（1，110）= 4.82，eta（2）（p）= 0.042，p = 0.03，而高龄仅在APOE 3纯合子中与记忆力下降相关：载脂蛋白E状态X年龄，F（1，110）= 4.92，eta（2）（p）= 0.043，p = 0.029。结论：相对轻微的危险因素的联合影响与记忆力下降有关，即使在健康成人中也是如此。
Objective: Vascular risk is associated with impairments in age-sensitive cognitive functions. However, age-associated differences in vascular risk and cognitive functioning can be explained in part by genetic factors, such as the presence of epsilon 4 allele of the Apolipoprotein E (APOE) gene. Although the links between these factors and cognitive deficits are frequently reported, their joint impact on healthy adults is rarely investigated. We hypothesized that phenotypic indicators of vascular risk (increased pulse pressure and high blood cholesterol levels) and genetic (APOE epsilon 4 allele) risk factors would exert a synergistic negative influence on episodic memory in healthy rather than typical adults. Method: We measured blood pressure, blood cholesterol levels, recognition memory, and free recall in a life span sample of normotensive adults 18-77 years of age. APOE genotype was determined from buccal cultures. Results: A general linear model analysis showed that elevated pulse pressure was associated with poorer memory but only in the carriers of epsilon 4 allele-APOE Status x PP interaction, F(1, 110) = 4.82, eta(2)(p) =.042, p =.03-whereas advanced age was associated with lower memory scores only in epsilon 3 homozygotes: APOE Status X Age, F(1, 110) = 4.92, eta(2)(p) = .043, p = .029. Conclusions: A joint influence of relatively mild risk factors is associated with reduced memory performance, even in healthy adults.