TOPPE: A framework for rapid prototyping of MR pulse sequences.

TOPPE: A framework for rapid prototyping of MR pulse sequences.
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DOI:
10.1002/mrm.26990
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发表时间:
2018-06
影响因子:
3.3
通讯作者:
Noll DC
Noll DC
中科院分区:
医学3区
文献类型:
--
作者:
Nielsen JF;Noll DC

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介绍MR脉冲序列快速原型的框架。我们提出了一个简单的文件格式,称为“TOPPE”,用于指定MR成像实验的所有细节,如梯度和射频(RF)波形和完整的扫描循环。此外,我们为GE扫描仪提供了一个TOPPE文件“解释器”,它是一个二进制可执行文件,用于加载TOPPE文件并在扫描仪上执行序列。我们还提供了MATLAB脚本,用于阅读和写入TOPPE文件,并在硬件执行之前预览序列。通过这种设置,脉冲序列编程器的任务减少到创建TOPPE文件,从而消除了对硬件特定编程的需要。不需要特定于序列的编译;解释器只需要编译一次(每次扫描仪软件升级)。我们证明TOPPE在三个不同的应用:k空间映射,非笛卡尔PRESTO全脑动态成像,并在大脑中使用非均匀磁化转移髓鞘映射。我们成功地实现并执行了三个示例序列。通过简单地更改各种TOPPE序列文件,使用单个二进制可执行文件(解释器)来执行几个不同的序列。TOPPE文件格式是MR成像实验的完整规范,基于(通常很小)数量的独特模块的任意序列。沿着GE解释器,TOPPE包括一个模块化和灵活的平台,用于新脉冲序列的快速原型制作。
To introduce a framework for rapid prototyping of MR pulse sequences. We propose a simple file format, called “TOPPE”, for specifying all details of an MR imaging experiment, such as gradient and radiofrequency (RF) waveforms and the complete scan loop. In addition, we provide a TOPPE file “interpreter” for GE scanners, which is a binary executable that loads TOPPE files and executes the sequence on the scanner. We also provide MATLAB scripts for reading and writing TOPPE files and previewing the sequence prior to hardware execution. With this setup, the task of the pulse sequence programmer is reduced to creating TOPPE files, eliminating the need for hardware-specific programming. No sequence-specific compilation is necessary; the interpreter only needs to be compiled once (for every scanner software upgrade). We demonstrate TOPPE in three different applications: k-space mapping, non-Cartesian PRESTO whole-brain dynamic imaging, and myelin mapping in the brain using inhomogeneous magnetization transfer. We successfully implemented and executed the three example sequences. By simply changing the various TOPPE sequence files, a single binary executable (interpreter) was used to execute several different sequences. The TOPPE file format is a complete specification of an MR imaging experiment, based on arbitrary sequences of a (typically small) number of unique modules. Along with the GE interpreter, TOPPE comprises a modular and flexible platform for rapid prototyping of new pulse sequences.
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