Assessment of PCB congener analytical methods: Do they meet risk assessment needs?
Assessment of PCB congener analytical methods: Do they meet risk assessment needs?
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DOI：
10.1007/s00244-002-2001-x
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发表时间：
2003-01-01
影响因子：
4
通讯作者：
Faustman, EM
中科院分区：
文献类型：
--
作者：
Judd, NL;Griffith, WC;Faustman, EM
当分析方法足够敏感时，特定同源多氯联苯分析允许使用毒性当量（TEQ）TCDD风险评估方法。许多分析鱼类样本中多氯联苯同系物的工作报告说，大多数样本为未检出;如果分析检测的限度超过了潜在的健康问题水平，这些数据对人类健康风险评估几乎没有用处。然而，提高分析灵敏度是昂贵的，并且在技术上是困难的。提出了一种通过定义关注的毒理学终点和可接受的风险水平来评估风险评估的分析灵敏度需求的方法。这一框架适用于评估美国一般人口和哥伦比亚河鱼类部落消费者的潜在多氯联苯毒性当量癌症风险，但可能很容易调整为其他情况。概率模型被用来计算必要的分析敏感性多氯联苯毒性当量癌症风险评估使用环境保护局的新草案的癌症风险斜率因子的四氯二苯并对二恶英和鱼类消费数据。对预计对多氯联苯毒性当量贡献最大的同系物多氯联苯126的理想分析灵敏度水平进行了估计，并与各种分析方法的检测限进行了比较。不同水平的分析灵敏度的方法的财务和健康价值进行了比较，使用的信息价值的方法，其中包括分析成本和潜在的健康结果的成本，并建议的风险评估实用程序的方法，认为相对健康保护的分析选项非货币。敏感性分析表明，平均消费率，癌症风险斜率因子的选择，和现有的多氯联苯污染的知识是规划多氯联苯同系物分析的重要考虑因素。
Congener-specific PCB analysis allows use of toxic equivalency (TEQ) TCDD-based risk assessment approaches when analytical methods are sufficiently sensitive. Many efforts to analyze fish samples for PCB congeners report the majority of samples as non-detects; these data are of little use for human health risk assessment if the limits of analytical detection exceed levels of potential health concern. However, increasing analytical sensitivity is costly and technically difficult. An approach to assess analytical sensitivity needs for risk assessment by defining toxicological endpoints of concern and acceptable risk levels is presented. This framework was applied to assessment of potential PCB TEQ cancer risks to the general United States population and tribal consumers of Columbia River fish, but may be easily adjusted for other situations. A probabilistic model was used to calculate the necessary analytical sensitivity for PCB TEQ cancer risk assessment using the Environmental Protection Agency's new draft cancer risk slope factor for TCDD and fish consumption data. Desired levels of analytical sensitivity were estimated for the congener expected to contribute the most to PCB TEQ, PCB 126, and compared to limits of detection for various analytical methods. The financial and health value of methods with different levels of analytical sensitivity were compared using a value of information approach, which includes analytical cost and cost of potential health outcomes, and a proposed risk assessment utility approach which considers the relative health protectiveness of analytical options non-monetarily. Sensitivity analyses indicate that average consumption rate, cancer risk slope factor choice, and knowledge of existing PCB contamination are important considerations for planning PCB congener analysis.