Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters.
Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters.
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DOI：
10.1016/j.pan.2016.12.010
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Banerjee S
中科院分区：
文献类型：
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作者：
Dauer P;Nomura A;Saluja A;Banerjee S
每年，全世界有近30万人被诊断出患有胰腺癌，并且相当数量的人死于这种疾病。胰腺癌的主要挑战之一是对标准化疗的耐药性。肿瘤的异质性、致密的成纤维细胞间质和肿瘤的侵袭性生物学都有助于化学抗性表型。此外，肿瘤微环境的非细胞组分如缺氧、基质细胞中的应激途径和免疫细胞分泌的细胞因子在协调肿瘤的化学抗性特性中具有决定性作用。在这篇综述中，我们系统地关注不同的微环境成分在决定胰腺肿瘤的化疗耐药性中所起的作用。
Every year, nearly 300,000 people are diagnosed with pancreatic cancer worldwide, and an equivalent number succumb to this disease. One of the major challenges of pancreatic cancer that contributes to its poor survival rates is the development of resistance to the standard chemotherapy. Heterogeneity of the tumor, the dense fibroblastic stroma, and the aggressive biology of the tumor all contribute to the chemoresistant phenotype. In addition, the acellular components of the tumor microenvironment like hypoxia, stress pathways in the stromal cells, and the cytokines that are secreted by the immune cells, have a definitive role in orchestrating the chemoresistant property of the tumor. In this review, we systematically focus on the role played by the different microenvironmental components in determining chemoresistance of pancreatic tumors.