OP-1 for cervical spine fusion: bridging bone in only 1 of 4 rheumatoid patients but prednisolone did not inhibit bone induction in rats.
OP-1 for cervical spine fusion: bridging bone in only 1 of 4 rheumatoid patients but prednisolone did not inhibit bone induction in rats.
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用于颈椎融合的 OP-1：仅在 4 名类风湿患者中的 1 名中桥接骨，但泼尼松龙不会抑制大鼠的骨诱导。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
P. Aspenberg
中科院分区：
文献类型：
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作者：
C. Jeppsson;H. Säveland;U. Rydholm;P. Aspenberg
我们在寰枢椎后路融合术中使用1型胶原载体上的OP-1（也称为BMP-7），以促进钢丝固定后的骨愈合。4例因类风湿性疾病导致寰椎和枢椎不稳定的患者接受了植入物。术后2个月、6个月、10个月行常规X线检查。在3例患者中，未检测到新骨形成。在1例患者中，6个月时新骨桥接融合部位。3例患者接受长期类固醇治疗，包括检测到骨形成的患者。为了确定类固醇治疗是否可能导致骨诱导率低，24只大鼠各自在腹部肌肉袋中接受OP-1植入物。将动物分为3组，分别给予生理盐水、泼尼松龙0.1或1.0mg/kg体重，直至术后3周处死。将标本脱钙用于组织学，并测量脱钙溶液中的钙量。各组均出现OP-1诱导的听骨形成，泼尼松龙对听骨形成无影响。因此，患者的失败可能有泼尼松龙治疗以外的原因。
We used OP-1 (also called BMP-7) on a collagen type-1 carrier in atlanto-axial posterior fusions to promote bony healing after wire fixation. 4 patients who had instability between the atlas and axis due to rheumatoid disease received the implants. The patients were examined with conventional radiography postoperatively at 2, 6 and 10 months. In 3 patients, no new bone formation was detectable. In 1 patient, new bone bridged the fusion site at 6 months. 3 patients were on chronic steroid treatment, including the patient in whom bone formation was detected. To determine whether steroid treatment could be responsible for the low rate of bone induction, 24 rats each received OP-1 implants in an abdominal muscle pouch. They were divided into 3 groups receiving saline, 0.1 or 1.0 mg/kg BW of prednisolone daily until they were killed 3 weeks postoperatively. Specimens were decalcified for histology and the amount of calcium in the decalcifying solution was measured. All groups showed ossicles induced by OP-1, and no effect of prednisolone was detected. Thus the failures in the patients may have causes other than prednisolone treatment.
影响因子：
1.8
作者：
U. Ripamonti;Barbara Van DenHeever;T. Sampath;M. Tucker;D. Rueger;A. Reddi
通讯作者：
U. Ripamonti;Barbara Van DenHeever;T. Sampath;M. Tucker;D. Rueger;A. Reddi