Medication compliance and persistence: Terminology and definitions
Medication compliance and persistence: Terminology and definitions
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DOI：
10.1111/j.1524-4733.2007.00213.x
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发表时间：
2008-01-01
期刊：
影响因子：
4.5
通讯作者：
Wong, Peter K.
中科院分区：
文献类型：
--
作者：
Cramer, Joyce A.;Roy, Anuja;Wong, Peter K.
目的：本研究的目的是提供指导的意义和使用的术语“遵守”和“持久性”，因为它们涉及到研究的药物use.Methods：文献综述和辩论适当的术语和definitions were carried.Results：服药依从性和服药持久性是两个不同的结构。用药依从性（同义词：依从性）是指在时间、剂量和频率方面与提供者关于日常治疗的建议的一致程度或范围。它可以被定义为“患者按照规定的间隔和给药方案的剂量起作用的程度。“药物持续性是指在规定的时间内继续治疗的行为。它可以被定义为“从开始治疗到停止治疗的持续时间。“没有总括性的术语结合这两个不同的construction.Conclusions：提供具体的定义，为遵守和持久性是非常重要的声音定量表达患者的药物给药的历史和他们的解释力的临床和经济事件。健康结果研究人员采用这些定义将为研究提供一致的框架和词汇。
Objective: The aim of the study is to provide guidance regarding the meaning and use of the terms "compliance" and "persistence" as they relate to the study of medication use.Methods: A literature review and debate on appropriate terminology and definitions were carried out.Results: Medication compliance and medication persistence are two different constructs. Medication compliance (synonym: adherence) refers to the degree or extent of conformity to the recommendations about day-to-day treatment by the provider with respect to the timing, dosage, and frequency. It may be defined as "the extent to which a patient acts in accordance with the prescribed interval, and dose of a dosing regimen." Medication persistence refers to the act of continuing the treatment for the prescribed duration. It may be defined as "the duration of time from initiation to discontinuation of therapy." No overarching term combines these two distinct constructs.Conclusions: Providing specific definitions for compliance and persistence is important for sound quantitative expressions of patients' drug dosing histories and their explanatory power for clinical and economic events. Adoption of these definitions by health outcomes researchers will provide a consistent framework and lexicon for research.