Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD:: The japan public health center-based prospective study cohort I
Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD:: The japan public health center-based prospective study cohort I
复制标题
DOI：
10.1080/07315724.2008.10719684
复制
发表时间：
2008-02-01
影响因子：
3.5
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Ishihara, Junko;Iso, Hiroyasu;Tsugane, Shoichiro
目的：探讨中年人膳食中叶酸、维生素B-6（VB 6）和维生素B-12（VB 12）与冠心病的关系。一共40个，从1990年至2000年，对803名年龄在40-59岁之间的社区受试者进行了随访，这些受试者先前没有心血管疾病和癌症的诊断，并完成了食物频率问卷调查。结果：经过468，472人年的随访，记录了251例冠心病事件。在校正年龄和性别后，冠心病和明确的心肌梗死与叶酸、VB 6和VB 12的饮食摄入量呈负相关，但在进一步校正吸烟、饮食和其他心血管危险因素后，这种相关性减弱。然而，在非多种维生素补充剂使用者中，VB 6摄入量最高与最低五分位数的多变量风险比（95%置信区间）对于总冠心病为0.60（0.37-0.97），对于明确的心肌梗死为0.52（0.29-0.91），与VB 12的负相关性略显着。低于中位数的摄入量的三种维生素或仅B-6的组合赋予了两次额外的风险，总coronary heartdisease.Conclusions：膳食摄入的VB 6与中年非多种维生素补充剂用户之间的冠心病的风险降低。叶酸和维生素B12也可能是冠心病的保护因素。
Objective: To investigate the association of dietary folate, vitamin B-6 (VB6) and vitamin B-12 (VB12) with the risk of coronary heart disease among middle-aged persons.Methods: A total of 40,803 subjects aged 40-59 years living in the community who were free of prior diagnoses of cardiovascular disease and cancer and who completed a food frequency questionnaire were followed from 1990-1992 to the end of 2001 in the Japan Public Health Center-based Prospective Study.Results: After 468,472 person-years of follow-up, 251 coronary heart disease incidents were documented. Coronary heart disease and definite myocardial infarction were inversely associated with dietary intake of folate, VB6 and VB12 after adjustment for age and sex, but the associations were attenuated after further adjustment for smoking, dietary and other cardiovascular risk factors. However, among non-multivitamin supplement users, multivariable hazard ratios (95% confidence intervals) in the highest vs. lowest quintiles of VB6 intake were 0.60 (0.37-0.97) for total coronary heart disease and 0.52 (0.29-0.91) for definite myocardial infarction, and the inverse associations with VB12 were marginally significant. The combination of below-median intake of three vitamins or of only B-6 conferred a twice excess risk of total coronary heart disease.Conclusions: Dietary intake of VB6 was associated with a reduced risk of coronary heart disease among middle-aged non-multivitamin supplement users. Dietary folate and VB12 were also suggested to be protective factors for coronary heart disease.