ROLE OF CARBON-MONOXIDE DIFFUSING-CAPACITY IN THE EARLY DETECTION OF MAJOR BLEOMYCIN-INDUCED PULMONARY TOXICITY
ROLE OF CARBON-MONOXIDE DIFFUSING-CAPACITY IN THE EARLY DETECTION OF MAJOR BLEOMYCIN-INDUCED PULMONARY TOXICITY
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DOI：
10.1111/j.1445-5994.1985.tb04015.x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
GILL, PG
中科院分区：
文献类型：
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作者：
BELL, MR;MEREDITH, DJ;GILL, PG
15 名恶性畸胎瘤患者和 12 名头颈部鳞状癌患者接受了博莱霉素治疗。进行了 CO 扩散能力 (DLco) 的常规测量。在治疗期间，两组的 DLco 测量值均显示出相似程度的逐渐下降。鳞状癌组中没有患者出现严重肺部毒性的临床或放射学证据。其中两名畸胎瘤患者遭受了致命的肺毒性，在出现任何重大肺毒性迹象之前，他们的 LDco 测量值与那些未出现重大临床毒性的患者的测量值没有什么不同。两名死亡患者在化疗期间均表现出肾功能持续下降，这可能是发生严重临床毒性的主要危险因素。该系列中 DLco 下降的幅度并不是出现严重放射毒性的患者的有用预测指标。
Fifteen patients with malignant teratoma and 12 with squamous cancer of the head and neck received treatment with bleomycin. Routine measurements of CO diffusing capacity (DLco) were performed. Both groups showed a gradual fall of similar magnitude in their DLco measurements during treatment. No patient in the group with squamous cancer developed clinical or radiological evidence of major pulmonary toxicity. Two of the teratoma patients suffered fatal pulmonary toxicity, and their LDco measurements before any signs of major pulmonary toxicity were no different from the measurements of those patients who remained free of major clinical toxicity. The 2 patients who died both showed a sustained reduction in renal function during chemotherapy which may have been a major risk foctor in the development of severe clinical toxicity. The magnitude of the decline in DLco in this series was not a useful predictor of those patients who developed severe and radiological toxicity.