A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats
A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats
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Ctns 基因缺失导致 LEA/Tohm 大鼠肾小管功能障碍和胱氨酸积聚
DOI：
10.1007/s00335-018-9790-3
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发表时间：
2018
期刊：
影响因子：
2.5
通讯作者：
Okamura Tadashi
中科院分区：
文献类型：
--
作者：
Shimizu Yukiko;Yanobu-Takanashi Rieko;Nakano Kenta;Hamase Kenji;Shimizu Toshiaki;Okamura Tadashi
Long-Evans Agglutination（莱亚/Tohm）大鼠是近年来建立的一种新的2型糖尿病大鼠模型。仅在雄性莱亚/Tohm大鼠中观察到糖尿病发作; 3然而，尿糖在糖尿病发作之前出现。为了阐明4种尿糖的遗传基础，我们利用（BN×莱亚）F2杂交后代进行了遗传连锁分析。5
The Long-Evans Agouti (LEA/Tohm) rat has recently been established as a new rat model of 2 type 2 diabetes. The onset of diabetes mellitus was observed only in male LEA/Tohm rats; 3 however, urinary glucose appeared before the onset of diabetes. To clarify the genetic basis of 4 urinary glucose, we performed genetic linkage analysis using (BN× LEA) F2 intercross progeny. 5