Tumors induce immune tolerance through activation of β-catenin/TCF4 signaling in dendritic cells: A novel therapeutic target for cancer immunotherapy.
Tumors induce immune tolerance through activation of β-catenin/TCF4 signaling in dendritic cells: A novel therapeutic target for cancer immunotherapy.
复制标题
肿瘤通过激活树突状细胞中的β-连环蛋白/TCF4 信号传导诱导免疫耐受：癌症免疫治疗的新治疗靶点。
DOI：
10.1080/2162402x.2015.1052932
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发表时间：
2015
期刊：
影响因子：
7.2
通讯作者：
Manicassamy,Santhakumar
中科院分区：
文献类型：
--
作者：
Suryawanshi,Amol;Manicassamy,Santhakumar
Tumors promote immune suppression and dendritic cells (DCs) play a key role in this. However, signaling networks that program DCs to induce immune suppression are unknown. In our recent study, we showed that tumors activate β-catenin/TCF4 in DCs programming them to a regulatory state, which promotes T regulatory responses while suppresses effector T cell responses. Thus, targeting DCs-β-catenin pathway represents a promising target for anticancer immunotherapy.
