The value of positron emission tomography for monitoring response to radiotherapy in head and neck cancer.
The value of positron emission tomography for monitoring response to radiotherapy in head and neck cancer.
复制标题
DOI：
10.1016/s1536-1632(03)00102-1
复制
发表时间：
2003-07-01
影响因子：
3.1
通讯作者：
Slotman, Ben J
中科院分区：
文献类型：
--
作者：
Klabbers, Bianca M;Lammertsma, Adriaan A;Slotman, Ben J
正电子发射断层扫描 (PET) 是一种分子成像技术，可以精确测量特定组织功能。使用 2-脱氧-2-[18F]氟-D-葡萄糖 (FDG) 对癌症进行分期是最广泛使用的诊断应用。由于 PET 能够定量测量功能变化，因此人们对其用于监测治疗反应的兴趣日益浓厚。本综述描述了 FDG 的生物学特性以及有关其在头颈部区域使用的方法学问题。此外，还讨论了 FDG 在预测和监测放射治疗反应方面的潜在用途。最后，回顾了一些其他示踪剂监测反应的潜力。
Positron emission tomography (PET) is a molecular imaging technique that allows for accurate measurements of specific tissue functions. Staging of cancer using 2-deoxy-2-[18F]fluoro-D-glucose (FDG) is the most widely used diagnostic application. As PET is able to measure functional changes quantitatively, interest is growing in its use for monitoring response to therapy. This review describes both biologic characteristics of FDG and methodologic issues regarding its use in the head and neck region. In addition, the potential use of FDG for predicting and monitoring response to radiotherapy is discussed. Finally, the potential of some other tracers for monitoring response is reviewed.