Maternal factors affecting the integrity of the late gestation placental barrier to murine enterovirus infection.
Maternal factors affecting the integrity of the late gestation placental barrier to murine enterovirus infection.
复制标题
影响妊娠晚期胎盘屏障完整性的母体因素对小鼠肠道病毒感染的影响。
DOI：
10.1086/514038
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Abzug,MJ
中科院分区：
文献类型：
--
作者：
Abzug,MJ
评估了可能损害妊娠晚期胎盘肠道病毒屏障完整性的母体因素。小鼠在妊娠第 10-13 天接种泰勒氏鼠脑脊髓炎病毒 (TMEV)，并在第 16-18 天处死。将来自高龄、强迫每天游泳、短期夹紧子宫胎盘血管、限制饮食摄入或细菌性腹膜炎的母鼠的胎盘和胎儿与来自感染 TMEV 的对照小鼠的组织进行比较。母亲年龄增加、锻炼和营养不良与胎儿体重减轻有关，子宫胎盘血流紊乱和严重营养不良与胎盘和胎儿形态异常有关。通过培养或原位杂交（或两者），在子宫胎盘血流中断、细菌性腹膜炎和年龄较大的母鼠的胎儿中偶尔观察到TMEV感染，但在对照感染小鼠的胎儿中却没有观察到TMEV感染。这表明母体因素，例如子宫胎盘血流受损、伴随感染和高龄，可能会增加经胎盘胎儿感染的风险。
Maternal factors that might impair the integrity of the late gestation placental barrier to enteroviruses were evaluated. Mice were inoculated with Theiler's murine encephalomyelitis virus (TMEV) on day 10–13 of gestation and sacrificed on day 16–18. Placentas and fetuses from dams with advanced age, forced daily swimming, short-term clamping of uteroplacental blood vessels, restricted dietary intake, or bacterial peritonitis were compared with tissues from TMEV-infected control mice. Increased maternal age, exercise, and malnutrition were associated with reduced fetal weight, and disturbed uteroplacental blood flow and severe malnutrition were associated with abnormal placental and fetal morphology. TMEV infection was observed sporadically by culture or in situ hybridization (or both) in fetuses from dams with interrupted uteroplacental blood flow, bacterial peritonitis, and older age but not in fetuses from control infected mice. This suggests that maternal factors, such as compromised uteroplacental blood flow, concomitant infection, and advanced age, may increase the risk of transplacental fetal infection.