Associations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis
Associations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis
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DOI：
10.1007/s11033-012-1955-7
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发表时间：
2012-12-01
影响因子：
2.8
通讯作者：
Lee, Young Ho
中科院分区：
文献类型：
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作者：
Song, Gwan Gyu;Bae, Sang-Cheol;Lee, Young Ho
本研究的目的是确定白细胞介素 23 受体 (IL-23R) 多态性是否会导致对类风湿性关节炎 (RA) 的易感性。使用(1)等位基因对比、(2)隐性模型、(3)显性模型和(4)加性模型，对IL-23R rs1343151、rs10489629、rs7517847、rs11209026、rs1004819和rs2201841多态性与RA之间的关联进行荟萃分析。荟萃分析共考虑了 8 篇文章中的 13 项研究，涉及 10,016 名 RA 患者和 11,967 名对照者。荟萃分析发现，总体人群中 RA 与 rs1343151 多态性的 A 等位基因之间存在显着关联（OR = 1.110，95 % CI = 1.056-1.168，p = 4.7 x 10(-6)）。按种族分层发现这种多态性与欧洲人的 RA 之间存在显着关联（OR = 1.105，95 % CI = 1.049-1.163，p = 1.4 x 10(-5)）。在欧洲人中还发现 RA 与 rs1343151 多态性的 A 等位基因携带者之间存在关联（OR = 1.135，95 % CI = 1.058-1.217，p = 4.0 x 10(-5)）。 Meta 分析显示，在总体人群（OR = 1.079，95% CI = 1.029-1.131，p = 0.002）和欧洲人（OR = 1.092，95% CI = 1.038-1.149，p = 0.001）中，RA 与 rs10489629 多态性的 A 等位基因之间存在显着相关性。隐性、显性和加性模型的荟萃分析显示与 rs10489629 多态性的 A 等位基因的荟萃分析相同的模式，即与欧洲人的 RA 显着相关。然而，未发现 IL-23R rs7517847、rs11209026、rs1004819 和 rs2201841 多态性与 RA 易感性之间存在关联。这项荟萃分析表明，IL-23R rs1343151 和 rs10489629 多态性与欧洲人 RA 的发展相关。这些发现表明，IL-23R 基因导致欧洲人群对 RA 易感性，但需要在其他种族群体中进一步研究这种关联。
The aim of this study was to determine whether interleukin-23 receptor (IL-23R) polymorphisms confer susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between the IL-23R rs1343151, rs10489629, rs7517847, rs11209026, rs1004819, and rs2201841 polymorphisms and RA using (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) the additive model. A total of 13 studies from eight articles involving 10,016 RA patients and 11,967 controls were considered in the meta-analysis. Meta-analysis identified a significant association between RA and the A allele of the rs1343151 polymorphism in the overall population (OR = 1.110, 95 % CI = 1.056-1.168, p = 4.7 x 10(-6)). Stratification by ethnicity identified a significant association between this polymorphism and RA in Europeans (OR = 1.105, 95 % CI = 1.049-1.163, p = 1.4 x 10(-5)). An association was also found between RA and the A allele carrier of the rs1343151 polymorphism in Europeans (OR = 1.135, 95 % CI = 1.058-1.217, p = 4.0 x 10(-5)). Meta-analysis revealed a significant association between RA and the A allele of the rs10489629 polymorphism in the overall population (OR = 1.079, 95 % CI = 1.029-1.131, p = 0.002) and in Europeans (OR = 1.092, 95 % CI = 1.038-1.149, p = 0.001). Meta-analyses of recessive, dominant, and additive models showed the same pattern as the meta-analysis of the A allele of the rs10489629 polymorphism, that is, a significant association with RA in Europeans. However, no association was found between the IL-23R rs7517847, rs11209026, rs1004819, and rs2201841 polymorphisms and RA susceptibility. This meta-analysis shows that the IL-23R rs1343151 and rs10489629 polymorphisms are associated with the development of RA in Europeans. These findings suggest that the IL-23R genes confer susceptibility to RA in the European population, but further study of this association is required in other ethnic groups.