ABSENCE OF WALLERIAN DEGENERATION DOES NOT HINDER REGENERATION IN PERIPHERAL-NERVE
ABSENCE OF WALLERIAN DEGENERATION DOES NOT HINDER REGENERATION IN PERIPHERAL-NERVE
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DOI：
10.1111/j.1460-9568.1989.tb00771.x
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发表时间：
1989-01-01
影响因子：
3.4
通讯作者：
GORDON, S
中科院分区：
文献类型：
--
作者：
LUNN, ER;PERRY, VH;GORDON, S
切断的周围神经远端的沃勒氏变性涉及粒单核细胞的入侵，粒单核细胞的存在是破坏髓鞘和启动雪旺细胞有丝分裂所必需的(Beuche和Frieed，1984)。轴突本身的远端退化被认为是通过自溶机制发生的。我们描述了一个小鼠品系(C57BL/6/Ola)，在该品系中，白细胞侵袭缓慢且稀疏。在这些小鼠中，证实了Beuche和Frieed，髓鞘的去除极其缓慢。一项新的发现是，轴突退化也非常缓慢。这是缺乏粒单核细胞募集的结果，因为如果补体类型3受体的单抗阻止了其他小鼠品系的这种募集(Rosen和Gordon，1987)，轴突退化就会再次放缓。令人惊讶的是，我们还发现，C57BL/6/Ola小鼠的神经再生不会因为远端残端存在基本完整的轴突、没有招募细胞、髓鞘碎片和雪旺细胞有丝分裂而受到阻碍。
Wallerian degeneration of the distal stump of a severed peripheral nerve involves invasion by myelomonocytic cells, whose presence is necessary for destruction of myelin and for initiating mitosis in Schwann cells (Beuche and Friede, 1984). Degeneration of the distal ends of the axons themselves is assumed to occur by autolytic mechanisms. We describe a strain of mice (C57BL/6/Ola) in which leucocyte invasion is slow and sparse. In these mice, confirming Beuche and Friede, myelin removal is extremely slow. A new finding is that axon degeneration is also very slow. This is a consequence of lack of recruitment of myelomonocytic cells for if such recruitment is prevented in other mouse strains by a monoclonal antibody against the complement type 3 receptor (Rosen and Gordon, 1987) axon degeneration is again slowed. We have also, surprisingly, found that nerve regeneration in the C57BL/6/Ola mice is not impeded by the presence of largely intact axons in the distal stump and absence of recruited cells, myelin debris and the absence of Schwann cell mitosis.