Action understanding requires the left inferior frontal cortex
Action understanding requires the left inferior frontal cortex
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DOI：
10.1016/j.cub.2006.01.033
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发表时间：
2006-03-07
期刊：
影响因子：
9.2
通讯作者：
Hamilton, AFD
中科院分区：
文献类型：
--
作者：
Pobric, G;Hamilton, AFD
许多研究已经证实，当手部动作被计划[1]、想象[2]、记忆[3]、模仿[4]甚至观察[5]时，下额叶皮层是活跃的。此外，有人提出，这些激活反映了一个模拟观察到的动作的过程，以允许它被理解[6，7]，从而完全感知。然而，左下额叶皮层的感知作用的直接证据是罕见的，并且语言[8]或运动[9]对报告的激活的贡献尚未被排除。我们使用重复经颅磁刺激（rTMS）在额下回知觉重量判断任务，以测试这一地区有助于行动理解的假设。该部位的rTMS损害了对人举起的箱子重量的判断，但对弹跳球的重量或刺激持续时间的判断没有影响，而对照部位的rTMS没有影响。这表明，左额下回的完整性是对他人行为做出准确知觉判断所必需的。
Numerous studies have established that inferior frontal cortex is active when hand actions are planned [1], imagined [2], remembered [3], imitated [4], and even observed [5]. Furthermore, it has been proposed that these activations reflect a process of simulating the observed action to allow it to be understood [6, 7] and thus fully perceived. However, direct evidence for a perceptual role for left inferior frontal cortex is rare, and linguistic [8] or motor [9] contributions to the reported activations have not been ruled out. We used repetitive transcranial magnetic stimulation (rTMS) over inferior frontal gyrus during a perceptual weight-judgement task to test the hypothesis that this region contributes to action understanding. rTMS at this site impaired judgments of the weight of a box lifted by a person, but not judgements of the weight of a bouncing ball or of stimulus duration, and rTMS at control sites had no impact. This demonstrates that the integrity of left inferior frontal gyrus is necessary to make accurate perceptual judgments about other people's actions.