Adenoviral E1A primes alveolar epithelial cells to PM10-induced transcription of interleukin-8
Adenoviral E1A primes alveolar epithelial cells to PM10-induced transcription of interleukin-8
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DOI：
10.1152/ajplung.2001.281.3.l598
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发表时间：
2001-09-01
影响因子：
4.9
通讯作者：
MacNee, W
中科院分区：
文献类型：
--
作者：
Gilmour, PS;Rahman, I;MacNee, W
人肺中腺病毒早期1A区（E1A）蛋白的存在与慢性阻塞性肺疾病（COPD）的风险增加有关，可能是通过一种与促炎反应放大有关的机制。我们假设炎症的增强是由于携带e1a的细胞中转录因子激活的增加，这可能对环境颗粒物质具有易感性
The presence of the adenoviral early region 1A (E1A) protein in human lungs has been associated with an increased risk of chronic obstructive pulmonary disease (COPD), possibly by a mechanism involving amplification of proinflammatory responses. We hypothesize that enhanced inflammation results from increased transcription factor activation in E1A-carrying cells, which may afford susceptibility to environmental particulate matter