The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.
The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.
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Ginsenoside RH2与癌症作斗争的方法：体外和体内的分子证据。
DOI：
10.1016/j.jgr.2022.09.011
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发表时间：
2023-03
影响因子：
6.3
通讯作者：
Fang Chen
中科院分区：
文献类型：
--
作者：
Qi-rui Hu;Yao Pan;Han-cheng Wu;Zhen-zhen Dai;Qing-xin Huang;Ting Luo;Jing Li;Ze-yuan Deng;Fang Chen
癌症是一个全球性的公共卫生问题，已成为全球第二大致死原因。考虑到放射或化疗的副作用，天然植物化学物质有望成为减轻副作用和并发症的治疗干预的替代方案。人参皂苷Rh2(GRh2)是从人参中提取的具有抗癌活性的主要植物化学成分。GRh2在体内外均能诱导癌细胞的凋亡和自噬，抑制癌细胞的增殖、转移、侵袭和血管生成。此外，GRh2还可作为化疗药物的佐剂，增强其抗癌作用，逆转其不良反应。本文对GRh2抗肿瘤作用的分子机制进行了综述，并提出了进一步开发和应用的方向。
Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion, and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeutics to enhance the anticancer effect and reverse the adverse effects. Here we summarized the understanding of the molecular mechanisms underlying the anticancer effects of GRh2 and proposed future directions to promote the development and application of GRh2.