Ocular pseudoexfoliation and cardiovascular disease: a national cross-section comparison study.
Ocular pseudoexfoliation and cardiovascular disease: a national cross-section comparison study.
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DOI：
10.4103/1947-2714.101987
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Harman LE
中科院分区：
文献类型：
--
作者：
French DD;Margo CE;Harman LE
假性剥脱是一种以细胞外基质沉积为特征的全身性疾病。导致这种情况的微纤维物质临床上可以在眼睛的前段看到，也可以在其他组织中发现，包括血管、皮肤、胆囊、肾脏、肺和心脏。本研究旨在确定眼部假性剥脱是否与特定的心血管疾病有关。在退伍军人健康管理数据库的帮助下，使用国际疾病分类，第九版，晶状体囊假性剥脱和假性剥脱性青光眼的临床修改进行横断面对比研究。选定的心血管疾病和心血管疾病的危险因素使用适当的医疗代码进行识别。以原发性开角型青光眼、慢性鼻窦炎、良性前列腺增生症患者为对照组。Logistic回归模型用于控制年龄、性别、种族和主要心血管危险因素。有6046名患者患有假性剥脱性青光眼；大约一半被诊断为假性剥脱性青光眼。在控制了年龄、性别、种族和主要心血管危险因素后，不同阶段的缺血性心脏病、心肌病和主动脉瘤与眼部假性剥脱显著相关。一般来说，与原发性开角型青光眼对照组相比，相关性不那么明显。与原发性开角型青光眼患者相比，眼部假性剥脱与心血管疾病的相关性一般较少且不明显。这些结果增加了早期研究的结果，这些研究表明开角型青光眼本身可能是某些心血管疾病的风险因素。
Pseudoexfoliation is a systemic disorder characterized by the deposition of extracellular matrix material. The microfibrillar material that gives rise to the condition is visible clinically in the anterior segment of the eye, and is also found in other tissues, including blood vessels, skin, gallbladder, kidneys, lungs, and heart. The present study aims to determine whether ocular pseudoexfoliation is associated with selected cardiovascular diseases. A cross-section comparison study was conducted with the help of the Veterans Health Administration databases, using the International Classification of Diseases, Ninth revision, Clinical Modification for pseudoexfoliation of lens capsule and pseudoexfoliation glaucoma. Selected cardiovascular diseases and risk factors for cardiovascular disease were identified using the appropriate medical codes. Patients with primary open-angle glaucoma, chronic sinusitis, and benign prostatic hyperplasia served as the comparison groups. A logistic regression model was used to control for age, gender, race, and major cardiovascular risk factors. There were 6,046 case patients with pseudoexfoliation; approximately half were diagnosed with pseudoexfoliation glaucoma. Various stages of ischemic heart disease, cardiomyopathy, and aortic aneurysm were significantly associated with ocular pseudoexfoliation, after controlling for age, gender, race, and major cardiovascular risk factors. Associations, in general, were less demonstrable relative to the primary open-angle glaucoma comparison group. Associations of ocular pseudoexfoliation with cardiovascular diseases were generally fewer and less pronounced when compared to patients with primary open-angle glaucoma. These results add to the results of earlier studies, which suggest that open-angle glaucoma itself might be a risk factor for certain cardiovascular disorders.