High Prevalence of Angiotropism in Congenital Melanocytic Nevi: An Analysis of 53 Cases
High Prevalence of Angiotropism in Congenital Melanocytic Nevi: An Analysis of 53 Cases
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DOI：
10.1097/dad.0b013e318260908c
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发表时间：
2013-04-01
影响因子：
1.1
通讯作者：
Barnhill, Raymond L.
中科院分区：
文献类型：
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作者：
Kokta, Victor;Hung, Tawny;Barnhill, Raymond L.
先天性黑素细胞痣（CMN）的发病机制尚未阐明。一个潜在的线索，他们的起源是在CMN痣细胞的血管向性观察。有趣的是，神经嵴干细胞（NCSC），黑素细胞的前体，在胚胎中表现出血管向性。越来越多的证据表明，NCSC在其到达皮肤的部分行程中沿着血管的外表面迁移。在黑色素瘤中，血管外迁移转移被描述为黑色素瘤细胞具有相当的血管向性和迁移。在这份报告中，我们首次系统地检查了53例CMN的血管紧张性频率。病变来自27名女性和26名男性，平均年龄为9.81岁（范围0.42-28岁）。痣大小0.3 ~ 40 cm，平均7.43 cm。53个病灶中有27个（50.9%）直径小于1.5 cm。16个痣（30.2%）为中等大小（1.5-19.9 cm），10个CMN（18.9%）为大/巨大型（直径>20 cm）。躯干是最常见的部位（23/53），其次是头部和颈部（17/53）。53个皮损中38个（71.7%）为复合性黑素细胞痣，15个（28.3%）为真皮痣。总之，在53例病例中的50例（94.3%）中观察到血管紧张性。因此，这种向血管性可能潜在地解释了引起CMN的前体细胞的起源。关于生长失调的进一步解释显然需要CMN的实际外观及其物理特征。
The mechanisms responsible for the development of congenital melanocytic nevi (CMN) have yet to be elucidated. A potential clue to their origin is the observation of angiotropism of nevus cells in CMN. Interestingly, neural crest stem cells (NCSCs), the precursors of melanocytes, demonstrate angiotropism in the embryo. There is accumulating evidence that NCSCs migrate along the external surfaces of vessels during a portion of their journey to the skin. Comparable angiotropism and migration of melanoma cells have been described as extravascular migratory metastasis in melanoma. In this report, we systematically examined for the first time, the frequency of angiotropism in 53 CMN. The lesions originated from 27 females and 26 males with an average age of 9.81 years (range 0.42-28 years). The mean nevus size was 7.43 cm (range 0.3-40 cm). Twenty-seven (50.9%) of the 53 lesions were less than 1.5 cm in diameter. Sixteen nevi (30.2%) were medium sized (1.5-19.9 cm), and 10 CMN (18.9%) were large/giant (>20 cm in diameter). The trunk was the most common location (23/53) followed by the head and neck (17/53). Thirty-eight (71.7%) of the 53 lesions were compound melanocytic nevi, and 15 (28.3%) of the 53 lesions were dermal nevi. In summary, angiotropism was observed in 50 (94.3%) of 53 cases. Consequently, such angiotropism may potentially explain the origin of the precursor cells giving rise to CMN. Further explanations concerning dysregulated growth are clearly needed for the actual appearance of CMN and their physical characteristics.