Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study
Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study
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苯妥英主要代谢物 5-(对羟基苯基)-5-苯基乙内酰脲 (p-HPPH) 对映体对慢性牙龈增生发生的影响：体内和体外研究
DOI：
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发表时间：
1995
影响因子：
2.9
通讯作者：
Kenji Ohtsubo
中科院分区：
文献类型：
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作者：
I. Ieiri;W. Goto;Shun Higuchi;K. Hirata;A. Toshitani;Shuhei Imayama;Y. Ohyama;Hideyuki Yamada;Kenji Ohtsubo
本研究的目的是评估苯妥英代谢物p-HPPH的(R)-和(S)-对映体在牙龈增生（GH）发病机制中的可能作用。大约98%的循环p-HPPH为(S)型。GH组与非GH组(R)-p-HPPH水平（0.055 vs 0.042 μg·ml−1）、R/S对映体/外消旋体比值（0.0313 vs 0.0232）差异均有统计学意义；GH患者血清(R)-p-HPPH水平升高。在单独的实验中，我们研究了p-HPPH对正常人真皮成纤维细胞增殖的影响。体外研究表明(R)-p-HPPH选择性刺激成纤维细胞生长。结果表明，最不丰富的代谢物(R)-p-HPPH对牙龈增生的毒性最大。
The purpose of this study was to assess the possible role of the (R)- and (S)- enantiomers of the phenytoin metabolite p-HPPH in the pathogenesis of gingival hyperplasia (GH). About 98% of circulating p-HPPH is in the (S)-form. There were significant differences between patients with and without GH in (R)-p-HPPH level (0.055 vs 0.042 μg·ml−1), both enantiomer/racemate level ratios, and R/S enantiomeric ratio (0.0313 vs 0.0232); an increase in serum (R)-p-HPPH level was observed in patients with GH. In separate experiments, the effect of p-HPPH enantiomers on the proliferation of the normal human dermal fibroblast was studied. The in vitro study showed that (R)-p-HPPH selectively stimulated fibroblast growth. The results suggest that the least abundant metabolite, (R)-p-HPPH, is the most toxic with respect to gingival hyperplasia.
影响因子：
3
作者：
T. M. Hassell;E. Stanek
通讯作者：
T. M. Hassell;E. Stanek
来自苯妥英增大的人牙龈的成纤维细胞产生无活性胶原酶的证据。
DOI：
10.1111/j.1600-0714.1982.tb00171.x
发表时间：
1982
期刊：
Journal of oral pathology
影响因子：
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作者：
Hassell,TM
通讯作者：
Hassell,TM