Transcription factor functionality and transcription regulatory networks
Transcription factor functionality and transcription regulatory networks
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DOI：
10.1039/b715909a
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Walhout, Albertha J. M.
中科院分区：
文献类型：
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作者：
Grove, Christian A.;Walhout, Albertha J. M.
现在，许多高质量的完整基因组序列是可用的，许多努力都集中在“第二基因组密码”，即决定如何实现基因组中每个基因的精确时空表达的密码。在这方面，阐明的转录调控网络，描述组合的转录电路的生物体的利益已成为有价值的，我们的理解基因表达在系统水平。这些网络描述了转录因子（TF）和它们在不同发育、生理或病理条件下调节的靶基因之间的物理和调节相互作用。高质量转录调控网络的映射不仅取决于所选择的实验或计算方法的准确性，而且还依赖于TF预测的质量。此外，TF的总库不仅由基因组的蛋白质编码能力决定，而且还由不同的蛋白质性质决定，包括二聚化、辅因子相互作用和翻译后修饰。在这里，我们讨论的因素，影响TF功能，因此，功能的网络中，他们的运作。
Now that numerous high-quality complete genome sequences are available, many efforts are focusing on the "second genomic code'', namely the code that determines how the precise temporal and spatial expression of each gene in the genome is achieved. In this regard, the elucidation of transcription regulatory networks that describe combined transcriptional circuits for an organism of interest has become valuable to our understanding of gene expression at a systems level. Such networks describe physical and regulatory interactions between transcription factors (TFs) and the target genes they regulate under different developmental, physiological, or pathological conditions. The mapping of high-quality transcription regulatory networks depends not only on the accuracy of the experimental or computational method chosen, but also relies on the quality of TF predictions. Moreover, the total repertoire of TFs is not only determined by the protein-coding capacity of the genome, but also by different protein properties, including dimerization, co-factor interactions and post-translational modifications. Here, we discuss the factors that influence TF functionality and, hence, the functionality of the networks in which they operate.