The FAR protein family of parasitic nematodes.
The FAR protein family of parasitic nematodes.
复制标题
DOI：
10.1371/journal.ppat.1010424
复制
发表时间：
2022-04
期刊：
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
脂肪酸和视黄醇结合蛋白 (FAR) 属于仅在线虫中发现的独特的分泌/分泌蛋白 (ESP) 家族。然而，我们对这些蛋白质的大部分了解仅限于它们对各种脂肪酸和视黄醇的体外结合特性，并且很少深入了解它们的体内功能或机制。然而，最近的研究表明，FAR 在植物和动物模型系统中引发免疫调节作用，可能是通过隔离参与免疫信号传导的脂质来实现的。这暗示了寄生线虫效应器与其宿主之间错综复杂的关系。
Fatty acid–and retinol-binding proteins (FARs) belong to a unique family of excreted/secreted proteins (ESPs) found exclusively in nematodes. Much of our understanding of these proteins, however, is limited to their in vitro binding characteristics toward various fatty acids and retinol and has provided little insight into their in vivo functions or mechanisms. Recent research, however, has shown that FARs elicit an immunomodulatory role in plant and animal model systems, likely by sequestering lipids involved in immune signaling. This alludes to the intricate relationship between parasitic nematode effectors and their hosts.
登录
查看更多内容
影响因子：
4
作者：
Fairfax KC;Vermeire JJ;Harrison LM;Bungiro RD;Grant W;Husain SZ;Cappello M
通讯作者：
Cappello M
影响因子：
3.8
作者：
Hotez PJ;Alvarado M;Basáñez MG;Bolliger I;Bourne R;Boussinesq M;Brooker SJ;Brown AS;Buckle G;Budke CM;Carabin H;Coffeng LE;Fèvre EM;Fürst T;Halasa YA;Jasrasaria R;Johns NE;Keiser J;King CH;Lozano R;Murdoch ME;O'Hanlon S;Pion SD;Pullan RL;Ramaiah KD;Roberts T;Shepard DS;Smith JL;Stolk WA;Undurraga EA;Utzinger J;Wang M;Murray CJ;Naghavi M
通讯作者：
Naghavi M
影响因子：
1.5
作者：
Basavaraju, S;Zhan, B;Hotez, PJ
通讯作者：
Hotez, PJ
影响因子：
4.8
作者：
Jordanova, Rositsa;Groves, Matthew R.;Tucker, Paul A.
通讯作者：
Tucker, Paul A.
影响因子：
1.5
作者：
Kuang, Lisha;Colgrave, Michelle L.;Wijffels, Gene
通讯作者：
Wijffels, Gene