Correlation of the SUVmax of FDG-PET and ADC values of diffusion-weighted MR imaging with pathologic prognostic factors in breast carcinoma
Correlation of the SUVmax of FDG-PET and ADC values of diffusion-weighted MR imaging with pathologic prognostic factors in breast carcinoma
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DOI：
10.1016/j.ejrad.2016.02.015
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发表时间：
2016-05-01
影响因子：
3.3
通讯作者：
Hirota, Shozo
中科院分区：
文献类型：
--
作者：
Kitajim, Kazuhiro;Yamano, Toshiko;Hirota, Shozo
目的：将FDG-PET/CT的原发灶最大标准化摄取值（SUVmax）和弥散加权成像（DWI）的表观弥散系数（ADC）值与乳腺癌患者的临床病理预后因素相关联。 材料和方法：214例216例肿块型浸润性乳腺癌患者在初始治疗前接受全身FDG-PET/CT和3-Tesla乳腺MRI（包括DWI）。分别使用FDG-PET/CT和DWI测量原发肿瘤的SUVmax和ADC值。组织学分析参数包括肿瘤大小、雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER2）和Ki-67的表达、核分级、组织学亚型和腋窝淋巴结（LN）转移。评估SUVmax、ADC值和病理预后因素之间的关系。结果：平均SUVmax和ADCmean分别为5.63+/-3.79（范围，1.2-24.17）和894+/-204×10-6mm(2/)s（范围，452-1550×10(-6)）。 SUVmax 和 ADCmean 值之间存在显着但较弱的负相关（相关系数 r = 0.30，p < 0.0001）。 SUVmax 与许多预后因素相关，例如肿瘤大小 (p < 0.0001)、ER (p = 0.00041)、PR (p = 0.00028)、HER2 (p = 0.00021) 和 Ki-67 (p < 0.0001) 的表达水平、核分级 (p < 0.0001)、组织学亚型 (p = 0.00061）、腋窝淋巴结转移（p < 0.0001）和 TNM 分期（p < 0.0001）。同时，ADC平均值与肿瘤大小（p = 0.013）、Ki-67表达（p = 0.0010）、组织学亚型（p = 0.00013）、腋窝淋巴结转移（p = 0.00059）和TNM分期（p = 0.0011）相关。结论：FDG-PET/CT上原发肿瘤SUVmax具有较强的相关性。与已知预后参数的关系，并且可能比 ADC 值更有助于预测乳腺癌的预后。 (C) 2016 Elsevier Ireland Ltd. 保留所有权利。
Purpose: To correlate both primary lesion maximum standardized uptake values (SUVmax) of FDG-PET/CT, and apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI) with clinicopathologic prognostic factors in patients with breast carcinoma.Materials and methods: 214 patients with 216 mass -type invasive breast carcinomas underwent whole body FDG-PET/CT and 3-Tesla breast MRI including DWI before initial therapy. The primary tumor's SUVmax and ADC values were measured using FDG-PET/CT and DWI, respectively. Histologic analysis parameters included tumor size, expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67, nuclear grade, histology subtype, and axillary lymph node (LN) metastasis. The relationships among SUVmax, ADC values, and pathologic prognostic factors were evaluated.Results: The mean SUVmax and ADCmean were 5.63 +/- 3.79 (range, 1.2-24.17) and 894 +/- 204 x 10-6 mm(2/)s (range, 452-1550 x 10(-6)), respectively. There was a significant but weak inverse correlation between the SUVmax and ADCmean values (correlation coefficient r = 0.30, p < 0.0001). SUVmax was associated with numerous prognostic factors such as tumor size (p < 0.0001), expression levels of ER (p = 0.00041), PR (p = 0.00028), HER2 (p = 0.00021), and Ki-67 (p < 0.0001), nuclear grade (p < 0.0001), histology subtype (p = 0.00061), axillary LN metastasis (p < 0.0001), and TNM staging (p < 0.0001). Meanwhile, ADCmean value was associated with tumor size (p = 0.013), expression of Ki-67 (p = 0.0010), histology subtype (p = 0.00013), axillary LN metastasis (p = 0.00059), and TNM staging (p = 0.0011).Conclusions: Primary tumor SUVmax on FDG-PET/CT has a stronger relationship with known prognostic parameters and may be a more useful for predicting the prognosis of breast carcinoma than ADC values. (C) 2016 Elsevier Ireland Ltd. All rights reserved.