Resveratrol affects the cross talk between immune and colon cancer cells
Resveratrol affects the cross talk between immune and colon cancer cells
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DOI：
10.1016/j.biopha.2012.10.008
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发表时间：
2013-02-01
影响因子：
7.5
通讯作者：
Salman, Hertzel
中科院分区：
文献类型：
--
作者：
Bergman, Michael;Levin, Gal Sahav;Salman, Hertzel
白藜芦醇是一种主要存在于葡萄及其种子中的天然多酚化合物，作为一种治疗辅助剂，在包括癌症预防在内的多种疾病中得到了广泛的认可。我们研究了白藜芦醇作为外周血单核细胞和两种人类结肠癌细胞系之间免疫对话的调节剂的作用，这种免疫对话可能通过细胞因子产生的改变来表达。白藜芦醇与未受刺激的单核细胞孵育，可引起IL-6、IL-1ra和IL-10的一定降低，TNF - α释放适度增加。另一方面，白藜芦醇不影响两种细胞系的癌细胞产生细胞因子。当白藜芦醇同时加入到免疫细胞和癌细胞中时，所检测的细胞因子的产生发生了剂量依赖性的改变。这些结果支持存在一种机制，除了那些已经描述的，可能解释白藜芦醇对肿瘤发生的预防作用。(C) 2012 Elsevier Masson SAS。版权所有。
Resveratrol, a natural polyphenolic compound found mainly in grapes and their seeds, is gaining a widespread appreciation as a therapeutic adjuvant in a variety of diseases including cancer prevention. We examined the effect of resveratrol as a modulator of the immune dialog between peripheral blood mononuclear cells and those from two human colon carcinoma lines, expressed by a possible alteration of cytokine production. Resveratrol, incubated with non-stimulated mononuclear cells, caused a certain reduction of IL-6, IL-1ra and IL-10, and a moderate increase of TNF alpha release. On the other hand, resveratrol did not affect cytokine production by cancer cells from both lines. When resveratrol was added to immune and cancer cells jointly, an altered dose-dependent decreased production of the examined cytokines was obtained. These results favor the existence of a mechanism, additional to those already described, that may explain the preventive effect of resveratrol on tumorigenesis. (C) 2012 Elsevier Masson SAS. All rights reserved.